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    Tim8 Tim8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32081, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tim8provided by FlyBase
    Official Full Name
    Tim8provided by FlyBase
    Primary source
    FLYBASE:FBgn0027359
    Locus tag
    Dmel_CG1728
    See related
    AllianceGenome:FB:FBgn0027359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD06593; CG1728; Dmel\CG1728
    Summary
    Predicted to enable protein transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Is expressed in adult head. Orthologous to human TIMM8B (translocase of inner mitochondrial membrane 8 homolog B). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Tim8 in Genome Data Viewer
    Location:
    10B6-10B6; 1-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11368445..11369283)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11262478..11263316)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene PTIP associated 1 Neighboring gene hopscotch Neighboring gene discs large 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes. Gnainsky Y, et al. Cell Rep, 2021 Jan 5. PMID 33406416
    2. Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. Zhu JY, et al. PLoS One, 2013. PMID 24386261, Free PMC Article
    3. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Gehrke S, et al. Cell Metab, 2015 Jan 6. PMID 25565208, Free PMC Article
    4. [Identification of C(2)M interacting proteins by yeast two-hybrid screening]. Yue SS, et al. Yi Chuan, 2015 Nov. PMID 26582530
    5. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Tim8
    Names
    CG1728-PA
    CG1728-PB
    Tim8-PA
    Tim8-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11368445..11369283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298191.1 → NP_001285120.1  Tim8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y1A3
      UniProtKB/TrEMBL
      X2JB87
      Conserved Domains (1) summary
      pfam02953
      Location:16 → 76
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_132485.4 → NP_572713.1  Tim8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y1A3
      UniProtKB/TrEMBL
      X2JB87
      Related
      FBpp0073338
      Conserved Domains (1) summary
      pfam02953
      Location:16 → 76
      zf-Tim10_DDP; Tim10/DDP family zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y1A3.1 Q9Y1A3
    X2JB87 X2JB87

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