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    fig fos intronic gene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    figprovided by FlyBase
    Official Full Name
    fos intronic geneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039694
    Locus tag
    Dmel_CG7615
    See related
    AllianceGenome:FB:FBgn0039694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7615; Dmel\CG7615; PPTC7
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in regulation of ubiquinone biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fig in Genome Data Viewer
    Location:
    99C1-99C1; 3-99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29779273..29780452, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25604995..25606174, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44953 Neighboring gene kayak Neighboring gene long non-coding RNA:CR46110 Neighboring gene shroud Neighboring gene R and B Neighboring gene Death related ICE-like caspase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene. Hudson SG, et al. Gene, 2008 Aug 15. PMID 18571877
    2. Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron. Hudson SG, et al. Genetics, 2007 Nov. PMID 18039871, Free PMC Article
    3. The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q(10) biosynthesis. González-Mariscal I, et al. Biochim Biophys Acta Bioenerg, 2018 Nov. PMID 30267671
    4. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
    5. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fos intronic gene
    Names
    CG7615-PA
    fig-PA
    fos intron gene
    fos-intronic gene
    NP_651724.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29779273..29780452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143467.4 → NP_651724.1  fos intronic gene [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MPH7, Q8SWZ0, Q9VAH4
      Related
      FBpp0084904
      Conserved Domains (1) summary
      cl00120
      Location:68 → 306
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAH4.1 Q9VAH4

    Gene LinkOut

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