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    Chchd3 Coiled-coil-helix-coiled-coil-helix domain containing 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43672, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Chchd3provided by FlyBase
    Official Full Name
    Coiled-coil-helix-coiled-coil-helix domain containing 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0010808
    Locus tag
    Dmel_CG1715
    See related
    AllianceGenome:FB:FBgn0010808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0205/14; 0353/13; 0812/02; 0966/01; 1274/08; anon-l; CG1715; ChChd3; Dmel\CG1715; dMIC19; l(3)03670; l(3)3670; l(3)96601; l(3)S127408; pMY8; x94917
    Summary
    Involved in cristae formation and mitochondrial fusion. Located in mitochondrial inner membrane. Part of MICOS complex. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study hypoplastic left heart syndrome. Orthologous to several human genes including CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Chchd3 in Genome Data Viewer
    Location:
    100B1-100B1; 3-102 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31052616..31053915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26878338..26879637, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Calcineurin A1 Neighboring gene pseudo Neighboring gene mir-4948 stem loop Neighboring gene Alkaline phosphatase 4 Neighboring gene discs overgrown Neighboring gene Sox100B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Kloss B, et al. Cell, 1998 Jul 10. PMID 9674431
    2. Drosophila MIC10b can polymerize into cristae-shaping filaments. Stephan T, et al. Life Sci Alliance, 2024 Apr. PMID 38253420, Free PMC Article
    3. A novel Drosophila alkaline phosphatase specific to the ellipsoid body of the adult brain and the lower Malpighian (renal) tubule. Yang MY, et al. Genetics, 2000 Jan. PMID 10628988, Free PMC Article
    4. double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Zilian O, et al. Development, 1999 Dec. PMID 10556065
    5. Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development. Deng Q, et al. Genetics, 2016 Aug. PMID 27317679, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Coiled-coil-helix-coiled-coil-helix domain containing 3
    Names
    CG1715-PA
    Chchd3-PA
    lethal (3) 03670

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31052616..31053915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143581.3 → NP_651838.1  Coiled-coil-helix-coiled-coil-helix domain containing 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24269, Q9VA18
      Related
      FBpp0085107
      Conserved Domains (2) summary
      pfam06747
      Location:163 → 195
      CHCH; CHCH domain
      pfam07956
      Location:103 → 193
      DUF1690; Protein of Unknown function (DUF1690)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24269 Q24269
    Q9VA18 Q9VA18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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