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    HPN hepsin [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707242, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HPNprovided by VGNC
    Official Full Name
    hepsinprovided by VGNC
    Primary source
    VGNC:VGNC:73513
    Locus tag
    EGK_10459
    See related
    Ensembl:ENSMMUG00000004844
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HPN in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (34461934..34487399)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (30953120..30978972)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106994725 Neighboring gene uncharacterized LOC114674222 Neighboring gene sodium voltage-gated channel beta subunit 1 Neighboring gene uncharacterized LOC106994727 Neighboring gene FXYD domain containing ion transport regulator 3 Neighboring gene leucine rich repeat LGI family member 4 Neighboring gene FXYD domain containing ion transport regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease hepsin
    Names
    Serine protease hepsin
    hepsin (transmembrane protease, serine 1)
    XP_014979029.1
    XP_014979030.1
    XP_014979031.1
    XP_014979032.1
    XP_014979033.1
    XP_014979034.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      34461934..34487399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015123547.1 → XP_014979033.1  serine protease hepsin isoform X4

      UniProtKB/TrEMBL
      A0A8J8XTY4, F6QHU6, F6XEI3, G7NM37, H9F7G7
      Related
      ENSMMUP00000031673.2, ENSMMUT00000038576.3
      Conserved Domains (3) summary
      smart00020
      Location:162 → 400
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:163 → 400
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:50 → 159
      Hepsin-SRCR; Hepsin, SRCR

    2. XM_015123545.2 → XP_014979031.1  serine protease hepsin isoform X3

      UniProtKB/TrEMBL
      H9F7G7
      Conserved Domains (3) summary
      smart00020
      Location:162 → 400
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:163 → 400
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:50 → 159
      Hepsin-SRCR; Hepsin, SRCR

    3. XM_015123543.2 → XP_014979029.1  serine protease hepsin isoform X1

      UniProtKB/TrEMBL
      H9F7G7
      Conserved Domains (3) summary
      smart00020
      Location:216 → 454
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:217 → 454
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:104 → 213
      Hepsin-SRCR; Hepsin, SRCR

    4. XM_015123546.2 → XP_014979032.1  serine protease hepsin isoform X3

      UniProtKB/TrEMBL
      H9F7G7
      Conserved Domains (3) summary
      smart00020
      Location:162 → 400
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:163 → 400
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:50 → 159
      Hepsin-SRCR; Hepsin, SRCR

    5. XM_015123548.2 → XP_014979034.1  serine protease hepsin isoform X2

      UniProtKB/TrEMBL
      F6XEJ3, H9F7G7
      Related
      ENSMMUP00000031672.3, ENSMMUT00000038575.3
      Conserved Domains (3) summary
      smart00020
      Location:216 → 454
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:217 → 454
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:104 → 213
      Hepsin-SRCR; Hepsin, SRCR

    6. XM_015123544.2 → XP_014979030.1  serine protease hepsin isoform X2

      UniProtKB/TrEMBL
      F6XEJ3, H9F7G7
      Conserved Domains (3) summary
      smart00020
      Location:216 → 454
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:217 → 454
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:104 → 213
      Hepsin-SRCR; Hepsin, SRCR
    Nucleotide Protein
    Heading Accession and Version

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