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    MLH3 mutL homolog 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701482, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MLH3provided by VGNC
    Official Full Name
    mutL homolog 3provided by VGNC
    Primary source
    VGNC:VGNC:82187
    See related
    Ensembl:ENSMMUG00000002911
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MLH3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (137128414..137164167, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (137402656..137438005, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene placental growth factor Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene U6 spliceosomal RNA Neighboring gene synapsin-2-like Neighboring gene uncharacterized LOC114679600 Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein Mlh3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257783.1 → NP_001244712.1  DNA mismatch repair protein Mlh3

      See identical proteins and their annotated locations for NP_001244712.1

      Status: PROVISIONAL

      Source sequence(s)
      JU333986
      UniProtKB/TrEMBL
      A0A5F7ZGI2, F7HAZ3
      Related
      ENSMMUP00000064701.1, ENSMMUT00000085079.1
      Conserved Domains (3) summary
      smart00853
      Location:1194 → 1373
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      137128414..137164167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028850280.1 → XP_028706113.1  DNA mismatch repair protein Mlh3 isoform X5

      UniProtKB/TrEMBL
      F7H1T6
      Related
      ENSMMUP00000003901.4, ENSMMUT00000004134.4
      Conserved Domains (3) summary
      smart00853
      Location:1126 → 1305
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
      cd16926
      Location:9 → 192
      HATPase_MutL-MLH-PMS-like; Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains

    2. XM_015144121.2 → XP_014999607.1  DNA mismatch repair protein Mlh3 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AS64
      Related
      ENSMMUP00000080795.1, ENSMMUT00000087718.1
      Conserved Domains (3) summary
      smart00853
      Location:1161 → 1340
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    3. XM_015144123.2 → XP_014999609.1  DNA mismatch repair protein Mlh3 isoform X4

      UniProtKB/TrEMBL
      F7H1T6
      Conserved Domains (3) summary
      smart00853
      Location:1159 → 1314
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    4. XM_015144122.2 → XP_014999608.1  DNA mismatch repair protein Mlh3 isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZGI2, A0A5F8ACA3
      Related
      ENSMMUP00000074601.1, ENSMMUT00000103957.1
      Conserved Domains (3) summary
      smart00853
      Location:1159 → 1338
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    5. XM_015144120.2 → XP_014999606.1  DNA mismatch repair protein Mlh3 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZIN1
      Related
      ENSMMUP00000064474.1, ENSMMUT00000108706.1
      Conserved Domains (3) summary
      smart00853
      Location:1194 → 1349
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    6. XM_015144124.2 → XP_014999610.1  DNA mismatch repair protein Mlh3 isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZGI2
      Conserved Domains (3) summary
      smart00853
      Location:1194 → 1278
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    RNA

    1. XR_003730902.1 RNA Sequence

    2. XR_003730903.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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