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    ARHGAP45 Rho GTPase activating protein 45 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 721173, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGAP45provided by VGNC
    Official Full Name
    Rho GTPase activating protein 45provided by VGNC
    Primary source
    VGNC:VGNC:69847
    See related
    Ensembl:ENSMMUG00000015301
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGAP45 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (838129..859011)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (835917..858093)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene ATP binding cassette subfamily A member 7 Neighboring gene RNA polymerase II, I and III subunit E Neighboring gene glutathione peroxidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    minor histocompatibility protein HA-1; rho GTPase-activating protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      838129..859011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015122327.2 → XP_014977813.2  rho GTPase-activating protein 45 isoform X3

      UniProtKB/TrEMBL
      A0A1D5QVM1
      Conserved Domains (3) summary
      smart00109
      Location:568 → 613
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00055
      Location:121 → 196
      FCH; Fes/CIP4 homology domain
      cl02570
      Location:625 → 835
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    2. XM_015122329.2 → XP_014977815.1  rho GTPase-activating protein 45 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QVM1
      Conserved Domains (3) summary
      smart00109
      Location:728 → 773
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:785 → 995
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:296 → 530
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_015122331.2 → XP_014977817.1  rho GTPase-activating protein 45 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QVM1
      Related
      ENSMMUP00000020066.4, ENSMMUT00000021454.4
      Conserved Domains (3) summary
      smart00109
      Location:700 → 745
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00055
      Location:281 → 356
      FCH; Fes/CIP4 homology domain
      cl02570
      Location:757 → 967
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version

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