Hr51 Hormone receptor 51 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hr51provided by FlyBase
Official Full Name: Hormone receptor 51provided by FlyBase
Primary source: FLYBASE:FBgn0034012
Locus tag: Dmel_CG16801
See related: AllianceGenome:FB:FBgn0034012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16801; CG16801/NR2E3; DHR51; Dmel\CG16801; fdx; HR51; Nr2e3; NR2E3; PNR; unf; UNF
Summary: Enables chromatin binding activity and heme binding activity. Involved in several processes, including imaginal disc-derived wing expansion; locomotor rhythm; and nervous system development. Located in nucleus. Is expressed in several structures, including LNv neurons; embryonic/larval midgut; ganglia; gland; and nephrocyte. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Orthologous to human NR2E3 (nuclear receptor subfamily 2 group E member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51F7-51F7; 2-74 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15331325..15339384)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11218830..11226889)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We demonstrated that a newly identified gene Rnb is an s-LNv-specific regulator of the molecular clock and essential for the generation of circadian locomotor behavior.
Title: A Screening of UNF Targets Identifies Rnb, a Novel Regulator of Drosophila Circadian Rhythms.
E75 and UNF bind to PER regulatory sequences and act together to enhance the CLK/CYC-mediated transcription of the PER gene.
Title: Transcriptional regulation via nuclear receptor crosstalk required for the Drosophila circadian clock.
Interest in genes that act downstream of unfulfilled has resulted in the identification of a growing number of unfulfilled interacting loci, providing the first glimpse into the composition of unfulfilled-dependent gene networks.[review]
Title: The unfulfilled gene and nervous system development in Drosophila.
UNF activates neuronal re-extension during development and drives developmental axon regrowth.
Title: Axon regrowth during development and regeneration following injury share molecular mechanisms.
Unfulfilled protein is required for free-running clocks in Drosophila pacemaker neurons
Title: The nuclear receptor unfulfilled is required for free-running clocks in Drosophila pacemaker neurons.
data indicate that unf is necessary for mushroom bodies axon extension and branching and that the formation of dorsal collaterals is more sensitive to the loss of unf function than medial projections.
Title: The unfulfilled gene is required for the development of mushroom body neuropil in Drosophila.
Unf governs axonal morphogenesis of multiple mushroom body neuron types, possibly through regulating neuronal subtype identity.
Title: Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons.
These data support the hypothesis that the wing expansion failure and the compromised fertility of unf/DHR51 mutants are the result of underlying neural defects.
Title: The unfulfilled/DHR51 gene of Drosophila melanogaster modulates wing expansion and fertility.
DHR51 binds nitric oxide and carbon monoxide. There is a possibility that DHR51 may be either a gas or a heme sensor.
Title: DHR51, the Drosophila melanogaster homologue of the human photoreceptor cell-specific nuclear receptor, is a thiolate heme-binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing expansion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hormone receptor 51

Names: CG16801-PC; Hr51-PC; drosophila hormone receptor 51; failure to deploy or expand; hormone receptor at 51; unfulfilled

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15331325..15339384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137188.3 → NP_611032.2 hormone receptor 51 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611032.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA01

Conserved Domains (2) summary

cd06950
Location:354 → 569

NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors

cd06970
Location:103 → 194

NR_DBD_PNR; DNA-binding domain of the photoreceptor cell-specific nuclear receptor (PNR) is composed of two C4-type zinc fingers