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    KIR3DH killer cell immunoglobulin-like receptor, 3 domains, hybrid [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 735306, updated on 18-Aug-2023

    Summary

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    Gene symbol
    KIR3DH
    Gene description
    killer cell immunoglobulin-like receptor, 3 domains, hybrid
    See related
    Ensembl:ENSMMUG00000009456
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    KIR; KIR3DL; KIR-3DL; KIR3DH4; KIR3DL8; KIR3DL08; KIR3DL14; KIR3DS04; Mamu-KIR
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    Genomic context

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    See KIR3DH in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (58210018..58220863, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) Unplaced Scaffold NW_015034336.1 (741..6363, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 Neighboring gene killer-cell Ig-like receptor KIR3DH5 Neighboring gene killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys. Hellmann I, et al. J Virol, 2012 Dec. PMID 23015705, Free PMC Article
    2. Association of activating KIR copy number variation of NK cells with containment of SIV replication in rhesus monkeys. Hellmann I, et al. PLoS Pathog, 2011 Dec. PMID 22194686, Free PMC Article
    3. Cloning of rhesus monkey killer-cell Ig-like receptors (KIRs) from early pregnancy decidua. Grendell RL, et al. Tissue Antigens, 2001 Nov. PMID 11844144
    4. Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques. Chaichompoo P, et al. Cell Immunol, 2010. PMID 20430371, Free PMC Article
    5. A splice site mutation converts an inhibitory killer cell Ig-like receptor into an activating one. Blokhuis JH, et al. Mol Immunol, 2009 Feb. PMID 19019442

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NK cells expressing high levels of activating KIRs efficiently kill SIVmac251-infected cells, and this efficient killing contributes to the NK cell-mediated control of replication of this virus during early infection.
      Title: Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.
    2. An association between copy numbers of KIR3DH genes and control of SIV replication in Mamu-A*01 rhesus monkeys that express restrictive TRIM5 alleles.
      Title: Association of activating KIR copy number variation of NK cells with containment of SIV replication in rhesus monkeys.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    killer cell immunoglobulin-like receptor, 3 domains, hybrid
    Names
    KIR-2DL/3DL phusion
    KIR-2DL/3DL protein
    KIR-3DL phusion
    KIR-3DL08 protein
    KIR3DL02/3DL08A
    KIR3DL02/3DL08A protein
    Killer-cell immunoglobulin-like receptor
    Mamu-KIR3DL08
    Mamu-KIR3DS04
    killer cell immunoglobulin-like receptor KIR3DH6
    killer cell immunoglobulin-like receptor KIR3DM5
    killer immunoglobulin-like receptor 3DS
    killer immunoglobulin-like receptor KIR3DL
    killer immunoglobulin-like receptor KIR3DL-like 2
    killer immunoglobulin-like receptor KIR3DL8
    killer immunoglobulin-like receptor KIRDL8
    killer-cell Ig-like receptor KIR3DL16
    killer-cell Ig-like receptor KIR3DL17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318346.1 → NP_001305275.1  killer cell immunoglobulin-like receptor, 3 domains, hybrid precursor

      Status: PROVISIONAL

      Source sequence(s)
      GU112330
      UniProtKB/TrEMBL
      A0A3F2XHD2
      Related
      ENSMMUP00000070387.1, ENSMMUT00000086646.1
      Conserved Domains (2) summary
      smart00410
      Location:34 → 104
      IG_like; Immunoglobulin like
      cl11960
      Location:126 → 220
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      58210018..58220863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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