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    MMP28 matrix metallopeptidase 28 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574250, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MMP28provided by VGNC
    Official Full Name
    matrix metallopeptidase 28provided by VGNC
    Primary source
    VGNC:VGNC:74755
    See related
    Ensembl:ENSMMUG00000022229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MMP28 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (32112299..32154957, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (29719554..29762028, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene growth arrest specific 2 like 2 Neighboring gene chromosome 16 C17orf50 homolog Neighboring gene TATA-box binding protein associated factor 15 Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene HEAT repeat containing 9 Neighboring gene C-C motif chemokine ligand 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrix metalloproteinase-28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278395.2 → NP_001265324.1  matrix metalloproteinase-28 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001265324.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      QNVO02000160
      UniProtKB/TrEMBL
      A0A1D5Q565, G7NH24
      Related
      ENSMMUP00000043180.2, ENSMMUT00000059918.2
      Conserved Domains (3) summary
      cd00094
      Location:321 → 510
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:129 → 284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam01471
      Location:31 → 86
      PG_binding_1; Putative peptidoglycan binding domain

    2. NM_001278396.2 → NP_001265325.1  matrix metalloproteinase-28 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      QNVO02000160
      UniProtKB/TrEMBL
      G7NH24
      Conserved Domains (4) summary
      cd04278
      Location:129 → 284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:129 → 284
      Peptidase_M10; Matrixin
      pfam01471
      Location:31 → 86
      PG_binding_1; Putative peptidoglycan binding domain
      cl02471
      Location:321 → 500
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      32112299..32154957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119024.2 → XP_014974510.1  matrix metalloproteinase-28 isoform X2

      Conserved Domains (3) summary
      cd04278
      Location:125 → 280
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:125 → 280
      Peptidase_M10; Matrixin
      pfam01471
      Location:36 → 82
      PG_binding_1; Putative peptidoglycan binding domain

    2. XM_015119023.2 → XP_014974509.1  matrix metalloproteinase-28 isoform X1

      Conserved Domains (3) summary
      cd04278
      Location:129 → 284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:129 → 284
      Peptidase_M10; Matrixin
      pfam01471
      Location:31 → 86
      PG_binding_1; Putative peptidoglycan binding domain

    3. XM_028835451.1 → XP_028691284.1  matrix metalloproteinase-28 isoform X3

      Conserved Domains (1) summary
      cd04278
      Location:44 → 199
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    Nucleotide Protein
    Heading Accession and Version

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