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    Jhe Juvenile hormone esterase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jheprovided by FlyBase
    Official Full Name
    Juvenile hormone esteraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010052
    Locus tag
    Dmel_CG8425
    See related
    AllianceGenome:FB:FBgn0010052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8425; Dmel\CG8425; DmJhe; JH; jhe; JHE
    Summary
    Enables carboxylesterase activity and juvenile-hormone esterase activity. Involved in behavioral response to ethanol; juvenile hormone catabolic process; and male mating behavior. Located in mitochondrion. Is expressed in adult fat body and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jhe in Genome Data Viewer
    Location:
    52E5-52E5; 2-77 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16119793..16122773)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12007298..12010278)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Aspartyl beta-hydroxylase Neighboring gene Juvenile hormone esterase duplication Neighboring gene uncharacterized protein Neighboring gene spinster

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Genetic analysis of differences in metabolism of juvenile hormone in lines of Drosophila virilis resistant and sensitive to heat stress]. Raushenbakh IIu, et al. Genetika, 1995 Feb. PMID 7721060
    2. Purification and kinetic characterisation of juvenile hormone esterase from Drosophila melanogaster. Campbell PM, et al. Insect Biochem Mol Biol, 1998 Jul. PMID 9718682
    3. Reversible juvenile hormone inhibition of ecdysteroid and juvenile hormone synthesis by the ring gland of Drosophila melanogaster. Richard DS, et al. Experientia, 1991 Oct 15. PMID 1936204
    4. Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance. Liu Z, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18275960
    5. [Genetic control of juvenile hormone metabolism in Drosophila melanogaster]. Gruntenko NE, et al. Genetika, 1996 Feb. PMID 8713622

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables juvenile-hormone esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in juvenile hormone catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    juvenile hormone esterase
    Names
    CG8425-PA
    CG8425-PB
    CG8425-PC
    JH esterase
    JH-esterase
    Jhe-PA
    Jhe-PB
    Jhe-PC
    NP_001163166.1
    NP_001286476.1
    NP_523758.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16119793..16122773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079034.5 → NP_523758.3  juvenile hormone esterase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523758.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA98, Q9BMT7
      Conserved Domains (1) summary
      pfam00135
      Location:40 → 527
      COesterase; Carboxylesterase family

    2. NM_001169695.2 → NP_001163166.1  juvenile hormone esterase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA98, Q9BMT7
      Conserved Domains (1) summary
      pfam00135
      Location:40 → 527
      COesterase; Carboxylesterase family

    3. NM_001299547.1 → NP_001286476.1  juvenile hormone esterase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA98, Q9BMT7
      Conserved Domains (1) summary
      pfam00135
      Location:40 → 527
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA98 A1ZA98
    Q9BMT7 Q9BMT7

    Gene LinkOut

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