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    Shawn shawn [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shawnprovided by FlyBase
    Official Full Name
    shawnprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031039
    Locus tag
    Dmel_CG14209
    See related
    AllianceGenome:FB:FBgn0031039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14209; CG33075; Dmel\CG14209; sh
    Summary
    Predicted to enable glutathione transmembrane transporter activity. Predicted to be involved in glutathione import into mitochondrion. Located in mitochondrion. Is expressed in adult head. Used to study neurodegenerative disease. Orthologous to several human genes including SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Shawn in Genome Data Viewer
    Location:
    18D3-18D3; 1-63 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19611526..19615617)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19505559..19509650)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S10b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tyler Neighboring gene uncharacterized protein Neighboring gene Translocase of inner membrane 9b Neighboring gene Phosphoseryl tRNA kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival. Slabbaert JR, et al. J Neurosci, 2016 Feb 10. PMID 26865615, Free PMC Article
    2. Functional Validation of Candidate Genes Detected by Genomic Feature Models. Rohde PD, et al. G3 (Bethesda), 2018 May 4. PMID 29519937, Free PMC Article
    3. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
    4. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    5. Stonewalling Drosophila stem cell differentiation by epigenetic controls. Maines JZ, et al. Development, 2007 Apr. PMID 17344229

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shawn
    Names
    CG14209-PB
    CG14209-PC
    CG14209-PD
    CG14209-PE
    Shawn-PB
    Shawn-PC
    Shawn-PD
    Shawn-PE
    complementation group X13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19611526..19615617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298519.1 → NP_001285448.1  shawn, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZT6, Q9VWG0
      Conserved Domains (1) summary
      pfam00153
      Location:178 → 265
      Mito_carr; Mitochondrial carrier protein

    2. NM_001031902.2 → NP_001027073.1  shawn, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZT6, Q9VWG0
      Conserved Domains (1) summary
      pfam00153
      Location:178 → 265
      Mito_carr; Mitochondrial carrier protein

    3. NM_001031901.2 → NP_001027072.1  shawn, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZT6, Q9VWG0
      Conserved Domains (1) summary
      pfam00153
      Location:178 → 265
      Mito_carr; Mitochondrial carrier protein

    4. NM_001031900.3 → NP_001027071.1  shawn, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027071.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZT6, Q9VWG0
      Conserved Domains (1) summary
      pfam00153
      Location:178 → 265
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWG0.2 Q9VWG0

    Gene LinkOut

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