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    Jasper JIL-1 anchoring and stabilizing protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43576, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Jasperprovided by FlyBase
    Official Full Name
    JIL-1 anchoring and stabilizing proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039743
    Locus tag
    Dmel_CG7946
    See related
    AllianceGenome:FB:FBgn0039743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7946; Dmel\CG7946; dP75; JASPer
    Summary
    Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to several human genes including HDGFL2 (HDGF like 2) and PSIP1 (PC4 and SRSF1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jasper in Genome Data Viewer
    Location:
    99D3-99D3; 3-100 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30052514..30054697)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25878236..25880419)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44046 Neighboring gene uncharacterized protein Neighboring gene spindle A Neighboring gene Ribonuclease P/MRP subunit p14 b Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p14 a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading. Dou K, et al. J Genet Genomics, 2020 Apr 20. PMID 32499180, Free PMC Article
    2. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Albig C, et al. Nat Commun, 2019 Nov 25. PMID 31767855, Free PMC Article
    3. The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae. Johannessen JA, et al. iScience, 2023 Oct 20. PMID 37720104, Free PMC Article
    4. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Wang CI, et al. Nat Struct Mol Biol, 2013 Feb. PMID 23295261, Free PMC Article
    5. Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases. Kline RA, et al. PLoS Genet, 2017 Mar. PMID 28362802, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading.
      Title: Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    JIL-1 anchoring and stabilizing protein
    Names
    CG7946-PA
    CG7946-PB
    Jasper-PA
    Jasper-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30052514..30054697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143511.3 → NP_651768.1  JIL-1 anchoring and stabilizing protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAA9
      Related
      FBpp0084927
      Conserved Domains (2) summary
      cd05834
      Location:8 → 88
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:320 → 440
      LEDGF; Lens epithelium-derived growth factor (LEDGF)

    2. NM_001276170.1 → NP_001263099.1  JIL-1 anchoring and stabilizing protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAA9
      Conserved Domains (2) summary
      cd05834
      Location:8 → 88
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:320 → 440
      LEDGF; Lens epithelium-derived growth factor (LEDGF)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAA9 Q9VAA9

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