wupA wings up A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wupAprovided by FlyBase
Official Full Name: wings up Aprovided by FlyBase
Primary source: FLYBASE:FBgn0283471
Locus tag: Dmel_CG7178
See related: AllianceGenome:FB:FBgn0283471
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7178; chrX:17947374..17947524; Dmel\CG7178; DmTpnI; DROTROPONI; fliH; hdp; Hdp; HDP; hdp-a; hdp2; HL-I; HL08042; HLI; Tn I; TnI; TpnI; wup-A; wupa; WupA
Summary: Involved in several processes, including adult somatic muscle development; muscle cell cellular homeostasis; and sarcomere organization. Located in striated muscle thin filament. Colocalizes with nucleus. Is expressed in several structures, including adult head; adult heart; larval muscle system; muscle cell; and seminal receptacle. Used to study adenocarcinoma; cardiomyopathy; dilated cardiomyopathy; and heart disease. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18105568..18116922, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17999601..18010955, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adult somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in striated muscle thin filament	HDA more info	PubMed
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info
part_of troponin complex	NAS Non-traceable Author Statement more info	PubMed

Names: CG7178-PA; CG7178-PB; CG7178-PC; CG7178-PD; CG7178-PE; CG7178-PF; CG7178-PG; CG7178-PH; CG7178-PI; CG7178-PJ; CG7178-PK; CG7178-PL; CG7178-PM; flightless H; flightless-H; haplo-lethal region I; held up; held-up; held-up2; heldup; heldup-a; troponin; troponin I; troponin-I; wings up; wings-up A; wupA-PA; wupA-PB; wupA-PC; wupA-PD; wupA-PE; wupA-PF; wupA-PG; wupA-PH; wupA-PI; wupA-PJ; wupA-PK; wupA-PL; wupA-PM