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    mfrn mitoferrin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mfrnprovided by FlyBase
    Official Full Name
    mitoferrinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039561
    Locus tag
    Dmel_CG4963
    See related
    AllianceGenome:FB:FBgn0039561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2H5; CG4963; Dmel\CG4963; dmfrn; HD35059; Mfrn
    Summary
    Enables iron ion transmembrane transporter activity. Involved in iron import into the mitochondrion; multicellular organismal-level iron ion homeostasis; and spermatid differentiation. Located in mitochondrial inner membrane. Is expressed in several structures, including adult Malpighian tubule; adult gut; anterior-posterior subdivision of organism; spermatid; and testis. Orthologous to several human genes including SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mfrn in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27942796..27948021, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23768518..23773743, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene minotaur Neighboring gene Nuclear receptor binding SET domain protein Neighboring gene Biorientation Defective 1 Neighboring gene Glycoprotein 93 Neighboring gene uncharacterized protein Neighboring gene Neprilysin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster. Lopez TE, et al. Arch Insect Biochem Physiol, 2016 Dec. PMID 27696504, Free PMC Article
    2. Mitochondrial iron supply is required for the developmental pulse of ecdysone biosynthesis that initiates metamorphosis in Drosophila melanogaster. Llorens JV, et al. J Biol Inorg Chem, 2015 Dec. PMID 26468126
    3. Overexpression of Drosophila frataxin triggers cell death in an iron-dependent manner. Edenharter O, et al. J Neurogenet, 2017 Dec. PMID 28838288
    4. Drosophila ZIP13 over-expression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria. Xue J, et al. J Neurochem, 2022 Mar. PMID 35038358
    5. Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster. Wan Z, et al. Biochem Biophys Res Commun, 2020 Nov 5. PMID 32873392

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster.
      Title: Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster.
    2. Study shows that mutations in the mitoferrin gene result in male sterility caused by developmental defects; from the sensitivity of the hypomorph mutants to low food iron levels it is concluded that mitochondrial iron is essential for spermatogenesis.
      Title: Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis.
    3. Mitoferrin overexpression upregulated Fer1HCH transcription.
      Title: Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron import into the mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitoferrin
    Names
    CG4963-PA
    anon-fast-evolving-2H5
    mfrn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27942796..27948021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143343.3 → NP_651600.1  mitoferrin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NHY6, Q9VAY3
      Related
      FBpp0084635
      Conserved Domains (2) summary
      PTZ00168
      Location:17 → 280
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:13 → 98
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAY3.1 Q9VAY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Chemical Information
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