DUSP13B dual specificity phosphatase 13B [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP13Bprovided by HGNC
Official Full Name: dual specificity phosphatase 13Bprovided by HGNC
Primary source: HGNC:HGNC:19681
See related: Ensembl:ENSG00000079393 MIM:613191; AllianceGenome:HGNC:19681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MDSP; TMDP; SKRP4; DUSP13
Summary: Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]
Expression: Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (75094434..75109191, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (75967932..75982690, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (76854192..76868949, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma.
Title: Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma.
Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor beta1-induced migration and drug resistance in A549 cells in vitro.
Title: Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor β1-induced migration and drug resistance in A549 cells in vitro.
data suggest an important role for DUSP13B in protection from external stress during spermatogenesis
Title: DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Here, we report the crystal structure of human TMDP at a resolution of 2.4 A. In spite of high sequence similarity with other DSPs, the crystal structure of TMDP shows distinct structural motifs and surface propertie
Title: Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity.
identified a gene on chromosome 10q22.2 using alternative ORFs to encode two distinct DSPs: the testis and skeletal muscle-specific TMDP and a novel muscle-restricted DSP(MDSP)
Title: Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-57611 (e-PCR)
- UniSTS:18448

RH94133 (e-PCR)
- UniSTS:91989

SHGC-3139 (e-PCR)
- UniSTS:13171

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MAP kinase phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in meiotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase 13B

Names: Testis- and skeletal muscle-specific DUSP; dual specificity phosphatase 13; testis- and skeletal-muscle-specific DSP

NP_001007273.1

EC 3.1.3.16

EC 3.1.3.48

NP_001007274.1

EC 3.1.3.16

EC 3.1.3.48

NP_001307771.1

EC 3.1.3.16

EC 3.1.3.48

NP_001307772.1

EC 3.1.3.16

EC 3.1.3.48

NP_001350443.1

EC 3.1.3.16

EC 3.1.3.48

NP_001399156.1

EC 3.1.3.16

EC 3.1.3.48

NP_057448.3

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033976.1 RefSeqGene

Range

14701..19777

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001007272.2 → NP_001007273.1 dual specificity protein phosphatase 13B isoform 2

See identical proteins and their annotated locations for NP_001007273.1

Status: REVIEWED

Description

Transcript Variant: TThis variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (2, also called TMDP-L2) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 2 were unsuccessful.

Source sequence(s)

AI971328, AK127886, AY674051

Consensus CDS

CCDS31224.1

UniProtKB/TrEMBL

U3KQA1

Conserved Domains (1) summary

cd00127
Location:95 → 238

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001007273.2 → NP_001007274.1 dual specificity protein phosphatase 13B isoform 3 precursor

See identical proteins and their annotated locations for NP_001007274.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also called TMDP-L1) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 3 were unsuccessful. Both variants 3 and 7 encode the same isoform (3).

Source sequence(s)

AI971328, AK127886, AY674051, BU580940

UniProtKB/TrEMBL

A0A9L9PXN7

Related

ENSP00000516748.1, ENST00000707120.1

Conserved Domains (1) summary

cd00127
Location:138 → 281

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001320842.2 → NP_001307771.1 dual specificity protein phosphatase 13B isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also known as TMDP-L1) has an alternate N-terminus, compared to isoform 9. Both variants 3 and 7 encode the same isoform (3).

Source sequence(s)

AI971328, AK127886, AY674051

UniProtKB/TrEMBL

A0A9L9PXN7

Conserved Domains (1) summary

cd00127
Location:138 → 281

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001320843.2 → NP_001307772.1 dual specificity protein phosphatase 13B isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (8) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (6, also known as TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).

Source sequence(s)

AI971328, AK057012, AY674051, DA898973

Consensus CDS

CCDS7346.1

UniProtKB/Swiss-Prot

A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82

UniProtKB/TrEMBL

U3KQA1

Related

ENSP00000516749.1, ENST00000707121.1

Conserved Domains (1) summary

cd14577
Location:28 → 191

DUSP13B; dual specificity protein phosphatase 13 isoform B
NM_001363514.2 → NP_001350443.1 dual specificity protein phosphatase 13B isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9) represents the allele encoded by the GRCh38 reference genome and encodes isoform 9.

Source sequence(s)

AL392111

Consensus CDS

CCDS86105.1

Related

ENSP00000475626.1, ENST00000478873.7

Conserved Domains (1) summary

cd00127
Location:181 → 324

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001412227.1 → NP_001399156.1 dual specificity protein phosphatase 13B isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses the same exon combination as variant 9 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (10) has a shorter N-terminus due to translation initiation at a downstream start codon, compared to isoform 9.

Source sequence(s)

CP068268
NM_016364.3 → NP_057448.3 dual specificity protein phosphatase 13B isoform 6

See identical proteins and their annotated locations for NP_057448.3

Status: REVIEWED

Description

Transcript Variant: TThis variant (6) uses a downstream in-frame start codon, compared to variant 9. The encoded isoform (6, also called TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).

Source sequence(s)

AB027004

Consensus CDS

CCDS7346.1

UniProtKB/Swiss-Prot

A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82

UniProtKB/TrEMBL

U3KQA1

Related

ENSP00000444580.1, ENST00000472493.6

Conserved Domains (1) summary

cd14577
Location:28 → 191

DUSP13B; dual specificity protein phosphatase 13 isoform B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

75094434..75109191 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

75967932..75982690 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001007274.1: Suppressed sequence

Description

NM_001007274.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_001007275.1: Suppressed sequence

Description

NM_001007275.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.