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    Vha44 Vacuolar H[+] ATPase 44kD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha44provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 44kD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287825
    Locus tag
    Dmel_CG8048
    See related
    AllianceGenome:FB:FBgn0287825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6072; ATP6V1C; ATP6V1C1; CG8048; Dmel\CG8048; l(2)02836; l(2)02836a; l(2)6072; l(2)SH1339; l(2)SH2 1339; vha44
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including Malpighian tubule; adult head; embryonic/larval midgut primordium; ganglia; and gut section. Used to study cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Vha44 in Genome Data Viewer
    Location:
    53B5-53C1; 2-79 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16324813..16336637, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12212318..12224142, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene HMG Coenzyme A synthase Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 62kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative Experimental Models for Studying Influenza Proteins, Host-Virus Interactions and Anti-Influenza Drugs. Chua SCJH, et al. Pharmaceuticals (Basel), 2019 Sep 30. PMID 31575020, Free PMC Article
    2. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Fan QX, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572941
    3. V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis. Gleixner EM, et al. Cell Rep, 2014 Jul 10. PMID 24953654
    4. RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism. Laiouar S, et al. Curr Biol, 2020 Apr 6. PMID 32059769
    5. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. Dow JA, et al. J Exp Biol, 1997 Jan. PMID 9050231

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. increased levels of V-ATPase C subunit induce a Eiger/JNK-dependent cell transformation within an epithelial organ that recapitulates early carcinoma stages.
      Title: Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 44kD subunit
    Names
    C subunit
    CG8048-PA
    CG8048-PB
    CG8048-PC
    CG8048-PE
    CG8048-PF
    V-ATPase C subunit
    Vha44-PA
    Vha44-PB
    Vha44-PC
    Vha44-PE
    Vha44-PF
    lethal (2) 02836a
    lethal (2) SH1339
    vacuolar ATPase C-subunit
    vacuolar H+ ATPase 44kD C subunit
    vacuolar H[+] ATPase 44 kDa subunit
    vacuolar H[+] ATPase 44kD C subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16324813..16336637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144207.2 → NP_001137679.1  vacuolar H[+] ATPase 44kD subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18365, Q0E956, Q5U1B8, Q869C0, Q95RY7, Q9V7N5, Q9V7N6, Q9V7N7
      UniProtKB/TrEMBL
      B7YZI0
      Conserved Domains (3) summary
      cd14785
      Location:570 → 596
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:547 → 822
      V-ATPase_C; V-ATPase subunit C
      cl15414
      Location:6 → 98
      V-ATPase_C; Subunit C of vacuolar H+-ATPase (V-ATPase)

    2. NM_166163.3 → NP_725564.1  vacuolar H[+] ATPase 44kD subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V7N5
      Related
      FBpp0086319
      Conserved Domains (2) summary
      cd14785
      Location:57 → 77
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:6 → 428
      V-ATPase_C; V-ATPase subunit C

    3. NM_166164.5 → NP_725565.3  vacuolar H[+] ATPase 44kD subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725565.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18365, Q0E956, Q5U1B8, Q869C0, Q95RY7, Q9V7N5, Q9V7N6, Q9V7N7
      UniProtKB/TrEMBL
      B7YZI0
      Conserved Domains (3) summary
      cd14785
      Location:570 → 596
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:547 → 822
      V-ATPase_C; V-ATPase subunit C
      cl15414
      Location:6 → 98
      V-ATPase_C; Subunit C of vacuolar H+-ATPase (V-ATPase)

    4. NM_057918.5 → NP_477266.1  vacuolar H[+] ATPase 44kD subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V7N5
      Related
      FBpp0086317
      Conserved Domains (1) summary
      pfam03223
      Location:6 → 374
      V-ATPase_C; V-ATPase subunit C

    5. NM_134313.4 → NP_599140.1  vacuolar H[+] ATPase 44kD subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V7N5
      Related
      FBpp0086320
      Conserved Domains (1) summary
      pfam03223
      Location:6 → 374
      V-ATPase_C; V-ATPase subunit C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZI0 B7YZI0
    Q9V7N5.5 Q9V7N5

    Gene LinkOut

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