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    MFS12 Major Facilitator Superfamily Transporter 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFS12provided by FlyBase
    Official Full Name
    Major Facilitator Superfamily Transporter 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0033234
    Locus tag
    Dmel_CG8791
    See related
    AllianceGenome:FB:FBgn0033234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.99; CG8791; Dmel\CG8791
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in several structures, including amnioserosa; anterior-posterior subdivision of organism; embryonic/larval salivary gland; fat body/gonad primordium; and plasmatocyte primordium. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MFS12 in Genome Data Viewer
    Location:
    43F2-43F2; 2-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7926653..7929922)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3814158..3817427)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cullin 1 Neighboring gene Odorant receptor 43b Neighboring gene Lysine demethylase 4A Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X Neighboring gene ribonuclease H1 Neighboring gene drosha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. Laridon B, et al. Gene Expr Patterns, 2008 Apr. PMID 18255354
    2. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. Bergwitz C, et al. PLoS One, 2012. PMID 22359624, Free PMC Article
    3. The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Velentzas PD, et al. Dev Cell, 2018 Nov 5. PMID 30318245, Free PMC Article
    4. A transcriptomics assessment of oxygen-temperature interactions reveals novel candidate genes underlying variation in thermal tolerance and survival. Boardman L, et al. J Insect Physiol, 2018 Apr. PMID 29038013
    5. Function-informed transcriptome analysis of Drosophila renal tubule. Wang J, et al. Genome Biol, 2004. PMID 15345053, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily transporter 12
    Names
    CG8791-PA
    CG8791-PB
    CG8791-PC
    MFS12-PA
    MFS12-PB
    MFS12-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7926653..7929922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136488.4 → NP_610332.3  major facilitator superfamily transporter 12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610332.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS66, Q9V334
      Related
      FBpp0087925
      Conserved Domains (2) summary
      cd06174
      Location:23 → 436
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:25 → 447
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. NM_001259267.1 → NP_001246196.1  major facilitator superfamily transporter 12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6S9
      Conserved Domains (2) summary
      cd06174
      Location:1 → 408
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:1 → 419
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    3. NM_001259266.1 → NP_001246195.1  major facilitator superfamily transporter 12, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6S9
      Conserved Domains (2) summary
      cd06174
      Location:1 → 408
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:1 → 419
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6S9 A0A0B4K6S9
    Q8MS66 Q8MS66
    Q8T9J4 Q8T9J4

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