Mccc2 Methylcrotonoyl-CoA carboxylase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mccc2provided by FlyBase
Official Full Name: Methylcrotonoyl-CoA carboxylase 2provided by FlyBase
Primary source: FLYBASE:FBgn0042083
Locus tag: Dmel_CG3267
See related: AllianceGenome:FB:FBgn0042083
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3267; Dmel\CG3267; FBgn0042083; l(2)4524; MCCC2_DROME
Summary: Predicted to enable ligase activity. Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Involved in regulation of eclosion. Predicted to be located in mitochondrial matrix. Predicted to be part of methylcrotonoyl-CoA carboxylase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study 3-methylcrotonyl-CoA carboxylase 2 deficiency. Human ortholog(s) of this gene implicated in 3-methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonyl-CoA carboxylase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42C8-42C8; 2-55 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6746381..6748954)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2633886..2636459)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 6747064-6747143 mobile_element_type = transposon:INE-1{}2361

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ligase activity	IEA Inferred from Electronic Annotation more info
contributes_to methylcrotonoyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to methylcrotonoyl-CoA carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in coenzyme A metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of eclosion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of methylcrotonoyl-CoA carboxylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of methylcrotonoyl-CoA carboxylase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Methylcrotonoyl-CoA carboxylase 2

Names: CG3267-PA; Mccc2-PA

NP_652724.1

EC 6.-.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6746381..6748954

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_144467.2 → NP_652724.1 Methylcrotonoyl-CoA carboxylase 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652724.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18364, Q8SXT5, Q9V9A7

UniProtKB/TrEMBL

H0RNI1

Related

FBpp0085460

Conserved Domains (2) summary

PLN02820
Location:27 → 578

PLN02820; 3-methylcrotonyl-CoA carboxylase, beta chain

cl23717
Location:82 → 254

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...