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    Tcs1 Threonyl-carbamoyl synthesis 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcs1provided by FlyBase
    Official Full Name
    Threonyl-carbamoyl synthesis 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0061361
    Locus tag
    Dmel_CG33786
    See related
    AllianceGenome:FB:FBgn0061361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10438; CG10438b; CG33005; CG33005-ORFB; CG33005ORFB; CG33786; Dmel\CG33786; Dromel_CG33786_FBtr0091786_mORF; sua5; tcs2; Tcs2
    Summary
    Predicted to enable L-threonylcarbamoyladenylate synthase and tRNA binding activity. Predicted to be involved in regulation of translational fidelity and tRNA threonylcarbamoyladenosine modification. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tcs1 in Genome Data Viewer
    Location:
    57A8-57A9; 2-91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20642466..20643785, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16529971..16531290, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene rigor mortis Neighboring gene uncharacterized protein Neighboring gene maf-S Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit K Neighboring gene DNA methyltransferase 1 associated protein 1 Neighboring gene Leucine-rich tendon-specific protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA. Thiaville PC, et al. RNA Biol, 2014. PMID 25629598, Free PMC Article
    2. Modulation of the Proteostasis Machinery to  Overcome Stress Caused by Diminished Levels of  t6A-Modified tRNAs in Drosophila. Rojas-Benítez D, et al. Biomolecules, 2017 Mar 6. PMID 28272317, Free PMC Article
    3. An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. Lin CJ, et al. RNA, 2015 Dec. PMID 26516084, Free PMC Article
    4. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. Hayden CA, et al. BMC Genomics, 2008 Feb 1. PMID 18237443, Free PMC Article
    5. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-threonylcarbamoyladenylate synthase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Threonyl-carbamoyl synthesis 1
    Names
    CG33786-PA
    L-threonylcarbamoyladenylate synthase type 1
    Tcs1-PA
    NP_001027444.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20642466..20643785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032273.4 → NP_001027444.1  Threonyl-carbamoyl synthesis 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYJ9
      Conserved Domains (1) summary
      pfam01300
      Location:46 → 225
      Sua5_yciO_yrdC; Telomere recombination
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYJ9 Q8SYJ9

    Gene LinkOut

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