betaGlu beta glucuronidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: betaGluprovided by FlyBase
Official Full Name: beta glucuronidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0270927
Locus tag: Dmel_CG2135
See related: AllianceGenome:FB:FBgn0270927
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta-GUS; CG2135; Dmel\CG2135; Glc; Glu; gus
Summary: Enables beta-glucuronidase activity. Predicted to be involved in carbohydrate metabolic process. Located in membrane. Is expressed in adult head. Used to study Sly syndrome. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31769293..31771848, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27595015..27597570, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables beta-glucuronidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-glucuronidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heparan sulfate proteoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

NP_651893.1

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The following sections contain reference sequences that belong to a specific genome build. Explain