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    anox anorexia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3771728, updated on 17-Dec-2024

    Summary

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    Official Symbol
    anoxprovided by FlyBase
    Official Full Name
    anorexiaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0064116
    Locus tag
    Dmel_CG33713
    See related
    AllianceGenome:FB:FBgn0064116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACBP; ACBP-ANK; Anox; cg1704; CG1704; CG33071; CG33071-ORFB; CG33071ORFB; CG33713; DmCG33713; Dmel\CG33713; Dromel_CG33713_FBtr0091704_mORF
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; mesoderm; and sense organ. Orthologous to human ACBD6 (acyl-CoA binding domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See anox in Genome Data Viewer
    Location:
    19F4-19F4; 1-65 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21317936..21319296, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21188963..21190323, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene transfer RNA:Tyrosine-GTA 2-1 Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 6 Neighboring gene SRA stem-loop interacting RNA binding protein 1 Neighboring gene Dullard Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene involved in the food preferences of larval Drosophila melanogaster. Ryuda M, et al. J Insect Physiol, 2008 Oct-Nov. PMID 18773904
    2. Identification of a novel gene, anorexia, regulating feeding activity via insulin signaling in Drosophila melanogaster. Ryuda M, et al. J Biol Chem, 2011 Nov 4. PMID 21917925, Free PMC Article
    3. The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1. Majerowicz D, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001070
    4. Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila. Liu Z, et al. Dev Growth Differ, 2011 Aug. PMID 21790556
    5. Automatic image analysis for gene expression patterns of fly embryos. Peng H, et al. BMC Cell Biol, 2007 Jul 10. PMID 17634097, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. anorexia is a novel gene regulating feeding activity via insulin signaling in Drosophila melanogaster
      Title: Identification of a novel gene, anorexia, regulating feeding activity via insulin signaling in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty-acyl-CoA binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anorexia
    Names
    CG33713-PA
    CG33713-PB
    anox-PA
    anox-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21317936..21319296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031915.2 → NP_001027086.1  anorexia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95S94, Q9VRG6
      Conserved Domains (4) summary
      cd00204
      Location:125 → 231
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00887
      Location:10 → 90
      ACBP; Acyl CoA binding protein
      pfam12796
      Location:125 → 212
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:148 → 179
      ANK; ANK repeat [structural motif]

    2. NM_001031914.2 → NP_001027085.1  anorexia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027085.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95S94, Q9VRG6
      Conserved Domains (4) summary
      cd00204
      Location:125 → 231
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00887
      Location:10 → 90
      ACBP; Acyl CoA binding protein
      pfam12796
      Location:125 → 212
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:148 → 179
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRG6 Q9VRG6

    Gene LinkOut

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