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    CalpC Calpain C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32597, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CalpCprovided by FlyBase
    Official Full Name
    Calpain Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260450
    Locus tag
    Dmel_CG3692
    See related
    AllianceGenome:FB:FBgn0260450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3692; Dmel\CG3692
    Old locus tag
    CG3692
    Summary
    Predicted to enable calcium ion binding activity. Located in cytoplasm. Is expressed in embryonic/larval salivary gland and organism. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; eosinophilic esophagitis; and muscular dystrophy. Orthologous to human CAPN13 (calpain 13); CAPN14 (calpain 14); and CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CalpC in Genome Data Viewer
    Location:
    14B13-14B13; 1-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16325763..16328523)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16219796..16222556)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene Cyclophilin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dorsal switch protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and RNA expression of a novel Drosophila calpain, Calpain C. Spadoni C, et al. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646209
    2. The intriguing Ca2+ requirement of calpain activation. Friedrich P. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451413
    3. The calpain-system of Drosophila melanogaster: coming of age. Friedrich P, et al. Bioessays, 2004 Oct. PMID 15382138
    4. Ca(2+)-calpains axis regulates Yki stability and activity in Drosophila. Zhai C, et al. J Genet Genomics, 2024 Oct. PMID 38663479
    5. The Ca2+-dependent protease Calpain A regulates Cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals. Fontenele M, et al. Mech Dev, 2009 Aug-Sep. PMID 19442719

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables calcium-dependent cysteine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in proteolysis IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain C
    Names
    CG3692-PA
    CalpC-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16325763..16328523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132890.3 → NP_573118.2  calpain C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573118.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NA1, Q95R89, Q9VXH6
      UniProtKB/TrEMBL
      T2GFF8
      Related
      FBpp0074005
      Conserved Domains (3) summary
      COG5126
      Location:567 → 648
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00044
      Location:7 → 329
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:346 → 483
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXH6.4 Q9VXH6

    Gene LinkOut

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