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    CG2747 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2747provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037541
    Locus tag
    Dmel_CG2747
    See related
    AllianceGenome:FB:FBgn0037541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2747
    Summary
    Enables molecular adaptor activity. Involved in retrograde transport, endosome to Golgi. Predicted to be active in endocytic vesicle. Is expressed in adult head; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human HEATR5A (HEAT repeat containing 5A) and HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2747 in Genome Data Viewer
    Location:
    84E8-84E9; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8016210..8030790, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3841932..3856512, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 95kD Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncoordinated 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene. Zheng C, et al. Epigenetics, 2024 Dec. PMID 38525798, Free PMC Article
    2. HEATR5B associates with dynein-dynactin and promotes motility of AP1-bound endosomal membranes. Madan V, et al. EMBO J, 2023 Dec 1. PMID 37872872, Free PMC Article
    3. Regulation of Drosophila eye development by the transcription factor Sine oculis. Jusiak B, et al. PLoS One, 2014. PMID 24586968, Free PMC Article
    4. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila. Sharma A, et al. Sci Rep, 2020 Nov 5. PMID 33154387, Free PMC Article
    5. Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein-protein interactions. Borner GH, et al. Mol Biol Cell, 2014 Oct 15. PMID 25165137, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2747-PA
    CG2747-PB
    CG2747-PC
    CG2747-PD
    CG2747-PE
    CG2747-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8016210..8030790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170077.2 → NP_001163548.1  uncharacterized protein Dmel_CG2747, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KD3
      Conserved Domains (1) summary
      sd00044
      Location:97 → 125
      HEAT; HEAT repeat [structural motif]

    2. NM_169205.3 → NP_731206.1  uncharacterized protein Dmel_CG2747, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSW1
      Related
      FBpp0081307
      Conserved Domains (1) summary
      sd00044
      Location:97 → 125
      HEAT; HEAT repeat [structural motif]

    3. NM_001275434.1 → NP_001262363.1  uncharacterized protein Dmel_CG2747, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGS8
      Conserved Domains (1) summary
      sd00044
      Location:145 → 173
      HEAT; HEAT repeat [structural motif]

    4. NM_001275435.1 → NP_001262364.1  uncharacterized protein Dmel_CG2747, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGF6
      Conserved Domains (1) summary
      sd00044
      Location:145 → 173
      HEAT; HEAT repeat [structural motif]

    5. NM_001170076.2 → NP_001163547.1  uncharacterized protein Dmel_CG2747, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494I1
      Conserved Domains (1) summary
      sd00044
      Location:145 → 173
      HEAT; HEAT repeat [structural motif]

    6. NM_141504.3 → NP_649761.2  uncharacterized protein Dmel_CG2747, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649761.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHW9
      Related
      FBpp0081308
      Conserved Domains (1) summary
      sd00044
      Location:145 → 173
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGF6 A0A0B4KGF6
    A0A0B4KGS8 A0A0B4KGS8
    Q32KD3 Q32KD3
    Q494I1 Q494I1
    Q7KSW1 Q7KSW1
    Q9VHW9 Q9VHW9

    Gene LinkOut

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