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    Phlpp PH domain leucine-rich repeat protein phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35178, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Phlppprovided by FlyBase
    Official Full Name
    PH domain leucine-rich repeat protein phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032749
    Locus tag
    Dmel_CG10493
    See related
    AllianceGenome:FB:FBgn0032749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10493; CT29458; Dmel\CG10493; dPHLPP; PP2C
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation and regulation of apoptotic process. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) and PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phlpp in Genome Data Viewer
    Location:
    37B12-37B13; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19059129..19063132)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19059129..19063132)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 3 Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PHLPP1 regulates CFTR activity and lumen expansion through AMPK. Lobert VH, et al. Development, 2022 Oct 15. PMID 35997536, Free PMC Article
    2. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Gao T, et al. Mol Cell, 2005 Apr 1. PMID 15808505
    3. Insulin signaling and the regulation of insect diapause. Sim C, et al. Front Physiol, 2013. PMID 23885240, Free PMC Article
    4. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PH domain leucine-rich repeat protein phosphatase
    Names
    CG10493-PA
    CG10493-PB
    Phlpp-PA
    Phlpp-PB
    NP_001260558.1
    NP_609938.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19059129..19063132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273629.1 → NP_001260558.1  PH domain leucine-rich repeat protein phosphatase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260558.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJ07
      UniProtKB/TrEMBL
      M9PBD5
      Conserved Domains (4) summary
      cd00116
      Location:256 → 410
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:136 → 158
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:279 → 359
      LRR_8; Leucine rich repeat
      cl00120
      Location:461 → 655
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_136094.2 → NP_609938.1  PH domain leucine-rich repeat protein phosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJ07
      UniProtKB/TrEMBL
      M9PBD5
      Related
      FBpp0080693
      Conserved Domains (4) summary
      cd00116
      Location:256 → 410
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:136 → 158
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:279 → 359
      LRR_8; Leucine rich repeat
      cl00120
      Location:461 → 655
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBD5 M9PBD5
    Q9VJ07.1 Q9VJ07

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