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    slow slowdown [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slowprovided by FlyBase
    Official Full Name
    slowdownprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035539
    Locus tag
    Dmel_CG7447
    See related
    AllianceGenome:FB:FBgn0035539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    blr; CG7447; CT22877; Dmel\CG7447; slomo; Slow
    Summary
    Predicted to enable signaling receptor binding activity. Involved in muscle attachment and synaptic target recognition. Located in muscle tendon junction. Is expressed in several structures, including Bolwig organ; dorsal ridge; epidermis; muscle cell; and sensory nervous system primordium. Orthologous to several human genes including EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slow in Genome Data Viewer
    Location:
    64B3-64B4; 3-12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4384442..4403181)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4384442..4403181)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dopamine/Ecdysteroid receptor Neighboring gene long non-coding RNA:CR44360 Neighboring gene uncharacterized protein Neighboring gene Syntaxin 17 Neighboring gene uncharacterized protein Neighboring gene Tumor protein p53 inducible nuclear protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction. Gilsohn E, et al. Development, 2010 Mar. PMID 20110313
    2. Using qualitative probability in reverse-engineering gene regulatory networks. Ibrahim ZM, et al. IEEE/ACM Trans Comput Biol Bioinform, 2011 Mar-Apr. PMID 20876933
    3. A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7. Zahoor MK, et al. Mol Genet Genomics, 2019 Jun. PMID 30656413
    4. Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes. Kurucz E, et al. Curr Biol, 2007 Apr 3. PMID 17363253
    5. Mechanical Control of Myotendinous Junction Formation and Tendon Differentiation during Development. Valdivia M, et al. Front Cell Dev Biol, 2017. PMID 28386542, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction
      Title: Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in muscle tendon junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    slowdown
    Names
    CG7447-PA
    CG7447-PB
    N-like
    blade runner
    slow-PA
    slow-PB
    slowdowm
    slowmotion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4384442..4403181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139641.3 → NP_647898.3  slowdown, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647898.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RQ1, Q9VZD0
      Related
      FBpp0073147
      Conserved Domains (3) summary
      smart00179
      Location:362 → 401
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:336 → 360
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07546
      Location:246 → 318
      EMI; EMI domain

    2. NM_176283.2 → NP_788461.1  slowdown, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RQ1, Q9VZD0
      Related
      FBpp0073148
      Conserved Domains (3) summary
      smart00179
      Location:362 → 401
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:336 → 360
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07546
      Location:246 → 318
      EMI; EMI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RQ1 Q95RQ1

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