Lip4 Lipase 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lip4provided by FlyBase
Official Full Name: Lipase 4provided by FlyBase
Primary source: FLYBASE:FBgn0032264
Locus tag: Dmel_CG6113
See related: AllianceGenome:FB:FBgn0032264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6113; dlip4; dLip4; Dmel\CG6113; lip4
Summary: Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in lipid droplet. Is expressed in adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31F5-31F5; 2-43 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10527572..10531778)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10527572..10531778)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that in flies, dFOXO regulates lipase 4 (Lip4), a Drosophila homologue of human acid lipases; dFOXO binds and activates the dLip4 promoter, in vitro and in vivo, and regulates dLip4 expression.
Title: dFOXO regulates transcription of a Drosophila acid lipase.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables serine hydrolase activity	HDA more info	PubMed
enables triacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lipase 4

Names: CG6113-PA; CG6113-PB; CG6113-PC; Lip4-PA; Lip4-PB; Lip4-PC; lipase4

NP_001188785.1

EC 3.1.-.-

EC 3.1.1.3

NP_001260356.1

EC 3.1.-.-

EC 3.1.1.3

NP_609418.1

EC 3.1.-.-

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10527572..10531778

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273427.1 → NP_001260356.1 lipase 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260356.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCU5

Conserved Domains (3) summary

PLN02872
Location:88 → 446

PLN02872; triacylglycerol lipase

pfam04083
Location:88 → 139

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

pfam12695
Location:121 → 253

Abhydrolase_5; Alpha/beta hydrolase family
NM_001201856.2 → NP_001188785.1 lipase 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188785.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRM3

Conserved Domains (3) summary

PLN02872
Location:74 → 430

PLN02872; triacylglycerol lipase

pfam04083
Location:74 → 125

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

pfam12695
Location:107 → 239

Abhydrolase_5; Alpha/beta hydrolase family
NM_135574.4 → NP_609418.1 lipase 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609418.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VKT9

Related

FBpp0079682

Conserved Domains (3) summary

PLN02872
Location:74 → 432

PLN02872; triacylglycerol lipase

pfam04083
Location:74 → 125

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

pfam12695
Location:107 → 239

Abhydrolase_5; Alpha/beta hydrolase family