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    Dhfr Dihydrofolate reductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42003, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhfrprovided by FlyBase
    Official Full Name
    Dihydrofolate reductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004087
    Locus tag
    Dmel_CG14887
    See related
    AllianceGenome:FB:FBgn0004087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14887; dhfr; DHFR; Dmel\CG14887
    Summary
    Enables dihydrofolate reductase activity. Predicted to be involved in dihydrofolate metabolic process; folic acid metabolic process; and tetrahydrofolate biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human DHFR (dihydrofolate reductase); DHFR2 (dihydrofolate reductase 2); and DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Dhfr in Genome Data Viewer
    Location:
    89B18-89B18; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16481167..16481878)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12306889..12307600)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46029 Neighboring gene Guanylyl cyclase at 89Da Neighboring gene Guanylyl cyclase at 89Db Neighboring gene Succinate dehydrogenase assembly factor 3 Neighboring gene Derlin-2 Neighboring gene Cadherin 89D

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NADP binding  
    enables NADP binding  
    enables dihydrofolate reductase activity  
    enables dihydrofolate reductase activity PubMed 
    enables dihydrofolate reductase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in dihydrofolate metabolic process  
    involved_in folic acid metabolic process  
    involved_in tetrahydrofolate biosynthetic process  
    involved_in tetrahydrofolate biosynthetic process  
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    dihydrofolate reductase
    Names
    CG14887-PA
    CG14887-PB
    Dhfr-PA
    Dhfr-PB
    NP_001036720.1
    NP_732147.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16481167..16481878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043255.2 → NP_001036720.1  dihydrofolate reductase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036720.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V302, P17719, Q9VEU4
      UniProtKB/TrEMBL
      G4LU61
      Conserved Domains (1) summary
      cd00209
      Location:4 → 179
      DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
    2. NM_169721.2 → NP_732147.1  dihydrofolate reductase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V302, P17719, Q9VEU4
      UniProtKB/TrEMBL
      G4LU61
      Related
      FBpp0082746
      Conserved Domains (1) summary
      cd00209
      Location:4 → 179
      DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
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