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    Indy-2 I'm not dead yet 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Indy-2provided by FlyBase
    Official Full Name
    I'm not dead yet 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0260466
    Locus tag
    Dmel_CG33933
    See related
    AllianceGenome:FB:FBgn0260466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.217; CG32921; CG33933; CG4961; Dmel\CG33933
    Old locus tag
    CG33933
    Summary
    Predicted to enable citrate transmembrane transporter activity; pyruvate transmembrane transporter activity; and succinate transmembrane transporter activity. Predicted to be involved in carboxylic acid transport; determination of adult lifespan; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Indy-2 in Genome Data Viewer
    Location:
    92C3-92C4; 3-67 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20042757..20048716)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15868479..15874438)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trade embargo Neighboring gene Regnase 1 Neighboring gene identity crisis Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene midlife crisis Neighboring gene Rhodopsin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extended life-span conferred by cotransporter gene mutations in Drosophila. Rogina B, et al. Science, 2000 Dec 15. PMID 11118146
    2. Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. Volkenhoff A, et al. Cell Metab, 2015 Sep 1. PMID 26235423
    3. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article
    4. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
    5. A phylogenetic analysis between humans and D. melanogaster: A repertoire of solute carriers in humans and flies. Ceder MM, et al. Gene, 2022 Jan 30. PMID 34673204

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pyruvate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in citrate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in pyruvate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in succinate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    I'm not dead yet 2
    Names
    CG33933-PA
    CG33933-PB
    Indy-2-PA
    Indy-2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20042757..20048716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032031.2 → NP_001027202.1  I'm not dead yet 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V353, Q95T83, Q9VDQ0
      Conserved Domains (2) summary
      TIGR00785
      Location:52 → 532
      dass; anion transporter
      cl21473
      Location:50 → 533
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...

    2. NM_001032030.1 → NP_001027201.1  I'm not dead yet 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027201.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V353, Q95T83, Q9VDQ0
      Conserved Domains (2) summary
      TIGR00785
      Location:52 → 532
      dass; anion transporter
      cl21473
      Location:50 → 533
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDQ0.2 Q9VDQ0

    Gene LinkOut

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