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    MFS9 Major Facilitator Superfamily Transporter 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFS9provided by FlyBase
    Official Full Name
    Major Facilitator Superfamily Transporter 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0038799
    Locus tag
    Dmel_CG4288
    See related
    AllianceGenome:FB:FBgn0038799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4288; Dmel\CG4288
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Predicted to be active in membrane. Is expressed in adult head; embryonic/larval hindgut; embryonic/larval posterior spiracle; and embryonic/larval salivary gland. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MFS9 in Genome Data Viewer
    Location:
    92E14-92E14; 3-68 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20507392..20512468, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16333114..16338190, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Metallothionein B Neighboring gene Odorant receptor 92a Neighboring gene Metallothionein E Neighboring gene Metallothionein D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glia transmit negative valence information during aversive learning in Drosophila. Miyashita T, et al. Science, 2023 Dec 22. PMID 38127757
    2. Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content. Daniels RW, et al. J Neurosci, 2004 Nov 17. PMID 15548661, Free PMC Article
    3. Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. Laridon B, et al. Gene Expr Patterns, 2008 Apr. PMID 18255354
    4. A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation. Regadas I, et al. Mol Cell, 2021 Apr 15. PMID 33631105
    5. A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Egli D, et al. Mol Cell Biol, 2006 Mar. PMID 16508004, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotransmitter loading into synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major facilitator superfamily transporter 9
    Names
    CG4288-PA
    CG4288-PB
    MFS9-PA
    MFS9-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20507392..20512468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142632.3 → NP_650889.1  major facilitator superfamily transporter 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2N3
      Related
      FBpp0083296
      Conserved Domains (2) summary
      cd06174
      Location:42 → 460
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:38 → 477
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. NM_169898.2 → NP_732515.1  major facilitator superfamily transporter 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2N3
      Related
      FBpp0083297
      Conserved Domains (2) summary
      cd06174
      Location:42 → 460
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:38 → 477
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2N3 Q7K2N3

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