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    Rbf2 Retinoblastoma-family protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41941, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbf2provided by FlyBase
    Official Full Name
    Retinoblastoma-family protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038390
    Locus tag
    Dmel_CG5083
    See related
    AllianceGenome:FB:FBgn0038390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5083; Dmel\CG5083; RB; rbf2; RBf2; RBF2
    Summary
    Enables transcription cis-regulatory region binding activity and transcription corepressor activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of transcription by RNA polymerase II. Part of DRM complex; Myb complex; and Rb-E2F complex. Is expressed in several structures, including antennal anlage; antennal primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1); RBL1 (RB transcriptional corepressor like 1); and RBL2 (RB transcriptional corepressor like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbf2 in Genome Data Viewer
    Location:
    89A8-89A8; 3-58 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15965446..15968138)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11791168..11793860)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene moira Neighboring gene Helicase 89B Neighboring gene long non-coding RNA:CR44133 Neighboring gene serpent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct developmental expression of Drosophila retinoblastoma factors. Keller SA, et al. Gene Expr Patterns, 2005 Feb. PMID 15661648
    2. Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila. Jacobs J, et al. Science, 2023 Jul 14. PMID 37440660
    3. Cell cycle expression of polarity genes features Rb targeting of Vang. Payankaulam S, et al. Cells Dev, 2022 Mar. PMID 34583062, Free PMC Article
    4. The N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner. Ahlander J, et al. PLoS One, 2008 Jul 30. PMID 18665226, Free PMC Article
    5. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. Stevaux O, et al. EMBO J, 2002 Sep 16. PMID 12234932, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbf1 and Rbf2 proteins are coexpressed at several stages of development, however, spatial and temporal differences are evident, including partly complementary patterns of expression in the embryonic central nervous system
      Title: Distinct developmental expression of Drosophila retinoblastoma factors.
    2. RBF1 and RBF2 interact with different subsets of E2F proteins; this enables the RBF proteins to regulate E2F-dependent transcription in distinct ways
      Title: Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2.
    3. RBF2 has a unique function in repressing E2F-regulated differentiation markers and dE2F2 and RBF2 are required to regulate different sets of target genes in different tissues
      Title: Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes.
    4. developmentally regulated COP9 signalosome (CSN) physically interacts with Rbf2 during embryogenesis
      Title: Retinoblastoma protein regulation by the COP9 signalosome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rb-E2F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Retinoblastoma-family protein 2
    Names
    CG5083-PA
    Rbf2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15965446..15968138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079648.4 → NP_524372.1  Retinoblastoma-family protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NIS1, Q9VF04
      Related
      FBpp0082667
      Conserved Domains (3) summary
      pfam01858
      Location:380 → 536
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:83 → 210
      DUF3452; Domain of unknown function (DUF3452)
      cl00050
      Location:564 → 679
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NIS1 Q9NIS1
    Q9VF04 Q9VF04

    Gene LinkOut

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