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    mus201 mutagen-sensitive 201 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mus201provided by FlyBase
    Official Full Name
    mutagen-sensitive 201provided by FlyBase
    Primary source
    FLYBASE:FBgn0002887
    Locus tag
    Dmel_CG10890
    See related
    AllianceGenome:FB:FBgn0002887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    55A11T; CG10890; CG32956; Dmel\CG10890; DmXPG; ERCC5; ESTS:55A11T; mus(2)201; mus-201; rad202; XPG; xpg/mus201; XPG[Dm]; XPG[DM]
    Summary
    Predicted to enable 5'-flap endonuclease activity. Involved in UV-damage excision repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mus201 in Genome Data Viewer
    Location:
    29C4-29C5; 2-32 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8438169..8442342)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8438169..8442342)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene D12 Neighboring gene Chromatin accessibility complex 14kD protein Neighboring gene uncharacterized protein Neighboring gene Aminoadipate-semialdehyde dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A deficiency for nucleotide excision repair strongly potentiates the mutagenic effectiveness of methyl bromide in Drosophila. Ballering LA, et al. Mutagenesis, 1994 Jul. PMID 7968583
    2. Induced mutagenic effects in the nucleotide excision repair deficient Drosophila mutant mus201(D1), expressing a truncated XPG protein. Calléja FM, et al. Mutat Res, 2001 Jan 5. PMID 11104904
    3. Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl)guanine levels in Drosophila. Nivard MJ, et al. Mutat Res, 2003 Aug 28. PMID 12943923
    4. denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster. Banga SS, et al. Proc Natl Acad Sci U S A, 1989 May. PMID 2541436, Free PMC Article
    5. Genetic and molecular genetic studies of mutation induction in an excision-defective strain of Drosophila melanogaster. Smith PD, et al. Prog Clin Biol Res, 1986. PMID 3092237

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UV-damage excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mutagen-sensitive 201
    Names
    CG10890-PC
    CG10890-PD
    mus201-PC
    mus201-PD
    NP_001027230.1
    NP_001027231.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8438169..8442342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032060.2 → NP_001027231.1  mutagen-sensitive 201, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4U2Q3, Q4U2Q5
      Conserved Domains (3) summary
      cd09904
      Location:940 → 1045
      H3TH_XPG; H3TH domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09868
      Location:1 → 121
      PIN_XPG; PIN domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      TIGR00600
      Location:1 → 1122
      rad2; DNA excision repair protein (rad2)

    2. NM_001032059.2 → NP_001027230.1  mutagen-sensitive 201, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4U2Q3, Q4U2Q5
      Conserved Domains (3) summary
      cd09904
      Location:940 → 1045
      H3TH_XPG; H3TH domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09868
      Location:1 → 121
      PIN_XPG; PIN domain of Xeroderma pigmentosum complementation group G (XPG) nuclease, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      TIGR00600
      Location:1 → 1122
      rad2; DNA excision repair protein (rad2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4U2H8 Q4U2H8
    Q4U2Q2 Q4U2Q2
    Q4U2Q3 Q4U2Q3
    Q4U2Q5 Q4U2Q5
    Q6AWP2 Q6AWP2
    Q9I7N6 Q9I7N6

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