Cip4 Cdc42-interacting protein 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cip4provided by FlyBase
Official Full Name: Cdc42-interacting protein 4provided by FlyBase
Primary source: FLYBASE:FBgn0035533
Locus tag: Dmel_CG15015
See related: AllianceGenome:FB:FBgn0035533
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11341; CG15015; cip4; CIP4; dcip4; dCIP4; DCIP4; Dmel\CG15015
Summary: Enables GTPase activating protein binding activity and lipid binding activity. Involved in several processes, including epithelial cell differentiation; negative regulation of cellular component organization; and plasma membrane tubulation. Located in several cellular components, including cleavage furrow; midbody; and neuromuscular junction. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; brain; central brain primordium; and embryonic/larval midgut primordium. Orthologous to several human genes including FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64B1-64B2; 3-12 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4322491..4364102, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4322491..4364102, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cip4 initially promotes membrane invagination and early-actin-based endosomal motility, and Nostrin makes contacts with microtubules through the kinesin Khc-73 for trafficking of recycling endosomes.
Title: Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis.
The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
Title: The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
This study proposed that dCIP4 restrains synaptic growth by inhibiting postsynaptic Glass bottom boat secretion through the Wsp-Arp2/3 pathway.
Title: dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal.
Cip4 integrates membrane trafficking and actin dynamics through WASP and WAVE.
Title: Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c4361901-4361048 mobile_element_type = transposon:FB{}Cip4[FB]

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst encapsulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane tubulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Cdc42-interacting protein 4

Names: CG15015-PA; CG15015-PB; CG15015-PC; CG15015-PD; CG15015-PE; CG15015-PF; CG15015-PG; CG15015-PH; CG15015-PI; CG15015-PJ; CG15015-PK; Cdc42-Interacting protein 4; Cip4-PA; Cip4-PB; Cip4-PC; Cip4-PD; Cip4-PE; Cip4-PF; Cip4-PG; Cip4-PH; Cip4-PI; Cip4-PJ; Cip4-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4322491..4364102 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274483.1 → NP_001261412.1 Cdc42-interacting protein 4, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261412.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBP3, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:369 → 445

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:540 → 598

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001274484.1 → NP_001261413.1 Cdc42-interacting protein 4, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261413.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE52, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:378 → 454

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:549 → 607

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259690.2 → NP_001246619.1 Cdc42-interacting protein 4, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246619.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE16, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:378 → 454

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:550 → 608

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259688.2 → NP_001246617.1 Cdc42-interacting protein 4, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246617.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF07, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:390 → 466

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:561 → 619

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259687.2 → NP_001246616.1 Cdc42-interacting protein 4, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246616.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND42, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:390 → 466

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:582 → 640

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259691.2 → NP_001246620.1 Cdc42-interacting protein 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246620.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE16, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:378 → 454

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:550 → 608

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_139636.4 → NP_647893.2 Cdc42-interacting protein 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647893.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8SYR8, Q9VZD7

Related

FBpp0073195

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:378 → 454

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:569 → 627

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259693.2 → NP_001246622.1 Cdc42-interacting protein 4, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246622.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF10, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:35 → 285

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:390 → 466

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:562 → 620

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259692.1 → NP_001246621.1 Cdc42-interacting protein 4, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246621.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND44, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:69 → 319

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:412 → 488

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:584 → 642

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001104031.2 → NP_001097501.1 Cdc42-interacting protein 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097501.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNK4, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:69 → 319

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:412 → 488

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:603 → 661

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001259689.1 → NP_001246618.1 Cdc42-interacting protein 4, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246618.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDH6, Q8SYR8

Conserved Domains (3) summary

cd07653
Location:32 → 281

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:374 → 450

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:566 → 624

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A8JNK4		A8JNK4
M9ND42		M9ND42
M9ND44		M9ND44
M9NDH6		M9NDH6
M9NE16		M9NE16
M9NF07		M9NF07
M9NF10		M9NF10
M9PBP3		M9PBP3
M9PE52		M9PE52
Q8SYR8		Q8SYR8
Q95SC6		Q95SC6
Q9VZD7		Q9VZD7