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    Gld Glucose dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gldprovided by FlyBase
    Official Full Name
    Glucose dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001112
    Locus tag
    Dmel_CG1152
    See related
    AllianceGenome:FB:FBgn0001112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1152; Dmel\CG1152; GDH; gld; GLD; glucose dehydrogenase; Go; l(3)84Cg
    Summary
    Predicted to enable oxidoreductase activity. Involved in sperm storage. Is expressed in several structures, including adult head; duct; embryonic dorsal epidermis; embryonic epipharynx; and sensory nervous system primordium. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gld in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7252063..7265703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3077785..3091425, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DTW domain containing 2 Neighboring gene Odorant-binding protein 84a Neighboring gene long non-coding RNA:CR44338 Neighboring gene Synaptotagmin 4 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. Iida K, et al. J Exp Biol, 2004 Feb. PMID 14718510
    2. GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. Cavener DR. J Mol Biol, 1992 Feb 5. PMID 1542121
    3. Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes. Cavener DR, et al. Mol Biol Evol, 1991 Jan. PMID 2002763
    4. Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster. Cox-Foster DL, et al. Genetics, 1990 Apr. PMID 2108903, Free PMC Article
    5. Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster. Cavener DR. Biochem Genet, 1980 Oct. PMID 6784715

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose dehydrogenase (FAD, quinone) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pupal chitin-based cuticle development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sperm storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm storage TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose dehydrogenase
    Names
    CG1152-PA
    CG1152-PB
    Gld-PA
    Gld-PB
    glucose oxidase
    NP_001350861.1
    NP_477503.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7252063..7265703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363924.1 → NP_001350861.1  glucose dehydrogenase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18173, Q9VI87
      UniProtKB/TrEMBL
      A0A2U8U0K3
      Conserved Domains (2) summary
      cl27052
      Location:64 → 601
      GMC_oxred_C; GMC oxidoreductase
      cl27343
      Location:29 → 95
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

    2. NM_058155.5 → NP_477503.1  glucose dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXV0, U3PT72
      Related
      FBpp0081114
      Conserved Domains (3) summary
      PRK02106
      Location:64 → 601
      PRK02106; choline dehydrogenase; Validated
      pfam00732
      Location:130 → 361
      GMC_oxred_N; GMC oxidoreductase
      pfam05199
      Location:456 → 599
      GMC_oxred_C; GMC oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2U8U0K3 A0A2U8U0K3
    P18173.3 P18173
    Q8SXV0 Q8SXV0

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