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    Prim2 DNA primase subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prim2provided by FlyBase
    Official Full Name
    DNA primase subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0259676
    Locus tag
    Dmel_CG5553
    See related
    AllianceGenome:FB:FBgn0259676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM13640; CG5553; Dmel\CG5553; Dmpol alpha; DNA polalpha; DNApol-alpha60; DNAprim; DNAprimase; GM13640; l(3)77ABe; l(3)j10B2; Pol; pol alpha; polalpha; Polalpha 60 kDa; PRI2; S(faf)240
    Summary
    Involved in DNA replication, synthesis of primer; compound eye morphogenesis; and mitotic cell cycle. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prim2 in Genome Data Viewer
    Location:
    77B6-77B6; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20359833..20361585, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20352933..20354685, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene kin17 Neighboring gene uncharacterized protein Neighboring gene Toll-9 Neighboring gene inturned

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterisation of the gene for the large subunit of the DNA primase from Drosophila melanogaster. Huikeshoven H, et al. Biochim Biophys Acta, 1999 Jun 9. PMID 10366721
    2. Joint effects of natural selection and recombination on gene flow between Drosophila ananassae populations. Chen Y, et al. Genetics, 2000 Jul. PMID 10880480, Free PMC Article
    3. A high molecular weight DNA polymerase from Drosophila melanogaster embryos. Purification, structure, and partial characterization. Banks GR, et al. J Biol Chem, 1979 Oct 10. PMID 114515
    4. Synthesis by the DNA primase of Drosophila melanogaster of a primer with a unique chain length. Conaway RC, et al. Proc Natl Acad Sci U S A, 1982 Aug. PMID 6812052, Free PMC Article
    5. Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos. Villani G, et al. J Biol Chem, 1981 Aug 10. PMID 6790535

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA primase subunit 2
    Names
    CG5553-PA
    DNA polymerase alpha 58,000 beta subunit
    DNA polymerase alpha 60,000 beta subunit
    DNA polymerase alpha 60kD
    DNA polymerase alpha 60kD subunit
    DNA primase
    DNA replication primer
    DNApol-alpha60
    DNAprim
    Prim2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20359833..20361585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143744.4 → NP_652001.2  DNA primase subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652001.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Q5, Q9VPH2
      UniProtKB/TrEMBL
      I1WYG8
      Related
      FBpp0077899
      Conserved Domains (1) summary
      cd07322
      Location:30 → 459
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPH2.2 Q9VPH2

    Gene LinkOut

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