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    Vps60 Vacuolar protein sorting 60 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps60provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 60provided by FlyBase
    Primary source
    FLYBASE:FBgn0036740
    Locus tag
    Dmel_CG6259
    See related
    AllianceGenome:FB:FBgn0036740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-74EFb; bs36h07.y1; CG6259; Chmp5; Dchmp5; Dmel\CG6259; VPS60
    Summary
    Involved in symbiont entry into host cell. Predicted to be active in multivesicular body. Is expressed in adult head and organism. Orthologous to human CHMP5 (charged multivesicular body protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps60 in Genome Data Viewer
    Location:
    74E2-74E2; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17620123..17621625, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17613223..17614725, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclin T Neighboring gene Ecdysone-induced protein 74EF Neighboring gene small Cajal body-specific RNA : MeU4-A65 Neighboring gene long non-coding RNA:CR44566 Neighboring gene anchor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Burtis KC, et al. Cell, 1990 Apr 6. PMID 2107982
    2. The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms. Bäumers M, et al. Biol Open, 2019 Sep 2. PMID 31412999, Free PMC Article
    3. Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. Marie PP, et al. J Extracell Vesicles, 2023 Mar. PMID 36872252, Free PMC Article
    4. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Michelet X, et al. Biol Cell, 2010 Jan 13. PMID 20059450
    5. An ESCRT module is required for neuron pruning. Loncle N, et al. Sci Rep, 2015 Feb 13. PMID 25676218, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 60
    Names
    CG6259-PA
    CG6259-PB
    Vps60-PA
    Vps60-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17620123..17621625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275065.1 → NP_001261994.1  vacuolar protein sorting 60, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVI9
      UniProtKB/TrEMBL
      M9PCV9
      Conserved Domains (1) summary
      cl21588
      Location:1 → 190
      Snf7; Snf7

    2. NM_140740.4 → NP_648997.1  vacuolar protein sorting 60, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVI9
      UniProtKB/TrEMBL
      M9PCV9
      Related
      FBpp0074964
      Conserved Domains (1) summary
      cl21588
      Location:1 → 190
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCV9 M9PCV9
    Q9VVI9.2 Q9VVI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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