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    MKP-4 MAPK Phosphatase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MKP-4provided by FlyBase
    Official Full Name
    MAPK Phosphatase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0031044
    Locus tag
    Dmel_CG14211
    See related
    AllianceGenome:FB:FBgn0031044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14211; Dmel\CG14211; DMKP-4; MAPK; Mkp4
    Summary
    Enables phosphatase activity. Involved in negative regulation of MAPK cascade. Located in nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MKP-4 in Genome Data Viewer
    Location:
    18D7-18D8; 1-63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19623114..19625729)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19517147..19519762)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 20 A Neighboring gene uncharacterized protein Neighboring gene enhancer of yellow 3 Neighboring gene Required for cell differentiation 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway. Sun L, et al. Cell Signal, 2008 Jul. PMID 18456458
    2. Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. Tang R , et al. Food Funct, 2019 Jul 17. PMID 31259337
    3. Ameliorative effect of bayberry leaves proanthocyanidins on high sugar diet induced Drosophila melanogaster. Wang M, et al. Front Pharmacol, 2022. PMID 36188544, Free PMC Article
    4. Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Ha EM, et al. Nat Immunol, 2009 Sep. PMID 19668222
    5. An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. Agrawal P, et al. G3 (Bethesda), 2016 Dec 7. PMID 27784754, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DMKP-4 is a Drosophila homologue of mammalian MAPK phosphatases, and may play important roles in the regulation of various developmental processes.
      Title: Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAPK phosphatase 4
    Names
    CG14211-PB
    CG14211-PC
    MKP-4-PB
    MKP-4-PC
    MKP-like
    NP_001259717.1
    NP_608332.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19623114..19625729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134488.2 → NP_608332.2  MAPK phosphatase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608332.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TD9, Q9VWF4
      Related
      FBpp0074510, FBtr0074741
      Conserved Domains (1) summary
      cd00127
      Location:39 → 176
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. NM_001272788.1 → NP_001259717.1  MAPK phosphatase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TD9, Q9VWF4
      Conserved Domains (1) summary
      cd00127
      Location:39 → 176
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWF4.1 Q9VWF4

    Gene LinkOut

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