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    Tim9b Translocase of inner membrane 9b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772213, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tim9bprovided by FlyBase
    Official Full Name
    Translocase of inner membrane 9bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027358
    Locus tag
    Dmel_CG17767
    See related
    AllianceGenome:FB:FBgn0027358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17767; CG33066; Dmel\CG17767; Dromel_CG12788_CG17767_FBtr0074_tim9b_uORF; Tim12; tim9; Tim9; Timm9
    Summary
    Predicted to enable unfolded protein binding activity. Involved in cellular response to hypoxia. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Predicted to be active in mitochondrial intermembrane space. Is expressed in adult heart and organism. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tim9b in Genome Data Viewer
    Location:
    18D3-18D7; 1-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19616663..19618537, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19510696..19512570, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tyler Neighboring gene shawn Neighboring gene uncharacterized protein Neighboring gene Phosphoseryl tRNA kinase Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 20 A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration. Periasamy A, et al. Sci Rep, 2022 Dec 14. PMID 36517509, Free PMC Article
    2. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    3. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Lee SJ, et al. Mol Biol Cell, 2008 Oct. PMID 18653470, Free PMC Article
    4. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. Hayden CA, et al. BMC Genomics, 2008 Feb 1. PMID 18237443, Free PMC Article
    5. Correlation between desiccation stress response and epigenetic modifications of genes in Drosophila melanogaster: An example of environment-epigenome interaction. Sharma V, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Oct. PMID 28801151

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    translocase of inner membrane 9b
    Names
    CG17767-PC
    CG17767-PD
    Tim9b-PC
    Tim9b-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19616663..19618537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031903.2 → NP_001027074.1  translocase of inner membrane 9b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4S9, Q9Y0V3
      UniProtKB/TrEMBL
      N0A2V5
      Conserved Domains (1) summary
      pfam02953
      Location:4 → 61
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_001031904.3 → NP_001027075.1  translocase of inner membrane 9b, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4S9, Q9Y0V3
      UniProtKB/TrEMBL
      N0A2V5
      Conserved Domains (1) summary
      pfam02953
      Location:4 → 61
      zf-Tim10_DDP; Tim10/DDP family zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y0V3.1 Q9Y0V3

    Gene LinkOut

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