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    Mipp2 Multiple inositol polyphosphate phosphatase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mipp2provided by FlyBase
    Official Full Name
    Multiple inositol polyphosphate phosphatase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0026060
    Locus tag
    Dmel_CG4317
    See related
    AllianceGenome:FB:FBgn0026060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4317; Dmel\CG4317; l(1)G0050; l(1)G0303; mipp2
    Summary
    Predicted to enable acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; and inositol phosphate phosphatase activity. Predicted to be involved in TOR signaling. Predicted to be located in extracellular exosome. Predicted to be part of TORC1 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mipp2 in Genome Data Viewer
    Location:
    5D4-5D4; 1-15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6082709..6091471, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5976742..5985504, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44959 Neighboring gene uncharacterized protein Neighboring gene raptor Neighboring gene Neprilysin 1 Neighboring gene Ca[2+]-channel protein alpha[[1]] subunit T Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration. Cheng YL, et al. Cell Rep, 2015 Dec 15. PMID 26628373, Free PMC Article
    2. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Chi H, et al. Genomics, 1999 Mar 15. PMID 10087200
    3. Longevity GWAS Using the Drosophila Genetic Reference Panel. Ivanov DK, et al. J Gerontol A Biol Sci Med Sci, 2015 Dec. PMID 25922346, Free PMC Article
    4. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
    5. Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. Bulat V, et al. J Cell Biol, 2014 Jan 6. PMID 24395637, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bisphosphoglycerate 3-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    multiple inositol polyphosphate phosphatase 2
    Names
    CG4317-PA
    Mipp2-PA
    NP_511055.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6082709..6091471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078500.4 → NP_511055.1  multiple inositol polyphosphate phosphatase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96420, Q9W438
      Related
      FBpp0070849
      Conserved Domains (1) summary
      cl11399
      Location:68 → 351
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96420 O96420
    Q8MQR0 Q8MQR0
    Q9W438 Q9W438

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