GA3OX1 gibberellin 3-oxidase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: GA3OX1
Official Full Name: gibberellin 3-oxidase 1
Primary source: TAIR:AT1G15550
Locus tag: AT1G15550
See related: Araport:AT1G15550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA GIBBERELLIN 3 BETA-HYDROXYLASE 1; ATGA3OX1; GA REQUIRING 4; GA4; GIBBERELLIN 3 BETA-HYDROXYLASE; gibberellin 3-oxidase 1; T16N11.6; T16N11_6
Summary: Involved in later steps of the gibberellic acid biosynthetic pathway. Activated by AGAMOUS in a cal-1, ap1-1 background. Deletion of 208 bp from -1016 to -809 (Delta-808) resulted in loss of GA-negative feedback (this sequence, which contains a 43-bp sequence GNFEI, was shown to be sufficient for GA-negative feedback).
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Gene Regulation via the Combination of Transcription Factors in the INDETERMINATE DOMAIN and GRAS Families.
Title: Gene Regulation via the Combination of Transcription Factors in the INDETERMINATE DOMAIN and GRAS Families.
DAG1 and the DELLA protein GAI cooperate in negatively regulating the AtGA3ox1 gene
Title: The DOF protein DAG1 and the DELLA protein GAI cooperate in negatively regulating the AtGA3ox1 gene.
Repression of GA3OX1 and GA3OX2 genes resulted in reduction of secondary wall thickening of fiber cells.
Title: [Molecular mechanism of AtGA3OX1 and AtGA3OX2 genes affecting secondary wall thickening in stems in Arabidopsis].
Data show the model of the gene expression feedback regulation of GID1, GA20ox, and GA3ox, and DELLA with gibberellin.
Title: Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling.
Data show that AtGA3ox1 is directly regulated by DAG1, and suggest that DAG1 is not a direct regulatory target of PIL5.
Title: The Dof protein DAG1 mediates PIL5 activity on seed germination by negatively regulating GA biosynthetic gene AtGA3ox1.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_101424.3

Function	Evidence Code	Pubs
enables gibberellin 3-beta-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables gibberellin 3-beta-dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables gibberellin 3-beta-dioxygenase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in gibberellin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gibberellin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gibberellin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to gibberellin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to red light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to red or far red light	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed

NP_173008.1

gibberellin 3-oxidase 1 (GA3OX1); CONTAINS InterPro DOMAIN/s: Isopenicillin N synthase (InterPro:IPR002283), Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: gibberellin 3-oxidase 2 (TAIR:AT1G80340.1); Has 8504 Blast hits to 8472 proteins in 995 species: Archae - 0; Bacteria - 1119; Metazoa - 109; Fungi - 1012; Plants - 4925; Viruses - 0; Other Eukaryotes - 1339 (source: NCBI BLink).