LAX3 uncharacterized protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LAX3
Official Full Name: uncharacterized protein
Primary source: TAIR:AT1G77690
Locus tag: AT1G77690
See related: Araport:AT1G77690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: like AUX1 3; T32E8.2; T32E8_2
Summary: Encodes an auxin influx carrier LAX3 (Like Aux1) that promotes lateral root emergence. Auxin-induced expression of LAX3 in turn induces a selection of cell-wall-remodelling enzymes, which are likely to promote cell separation in advance of developing lateral root primordia.
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Genomic context

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See LAX3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (29200417..29203418, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study conclude that sequential LBD29 and LAX3 induction by auxin is required to coordinate cell separation and organ emergence.
Title: Lateral root emergence in Arabidopsis is dependent on transcription factor LBD29 regulation of auxin influx carrier LAX3.
Results suggest that Lateral Organ Boundaries Domain16 and 18 (LBD16 and LBD18) are important regulators of lateral root (LR) initiation and development downstream of AUXIN1 (AUX1) and LIKE-AUXIN3 (LAX3) auxin influx carriers.
Title: Lateral Organ Boundaries Domain16 and 18 Act Downstream of the AUXIN1 and LIKE-AUXIN3 Auxin Influx Carriers to Control Lateral Root Development in Arabidopsis.
we observed fewer and more spaced vascular bundles in quadruple mutants plants of the auxin influx carriers aux1lax1lax2lax3
Title: Auxin influx carriers control vascular patterning and xylem differentiation in Arabidopsis thaliana.
A single cell model of the LAX3 and IAA14 auxin response was formulated and used to demonstrate that hysteresis and bistability may explain the experimentally observed 'all-or-nothing' LAX3 spatial expression pattern in cortical cells.
Title: Modelling of Arabidopsis LAX3 expression suggests auxin homeostasis.
Sequential induction of auxin efflux (PIN3) and influx (LAX3) carriers regulates lateral root emergence in Arabidopsis.
Title: Sequential induction of auxin efflux and influx carriers regulates lateral root emergence.
The nematode protein 19C07 interacts with the auxin influx transporter AtLAX3. LAX3 is upregulated in developing syncytia.
Title: The novel cyst nematode effector protein 19C07 interacts with the Arabidopsis auxin influx transporter LAX3 to control feeding site development.
mutant analysis demonstrates that the auxin influx carrier LAX3 is indispensable for proper hook formation, whereas the auxin influx carrier AUX1 is involved in the hook exaggeration phenotype induced by ethylene
Title: The auxin influx carriers AUX1 and LAX3 are involved in auxin-ethylene interactions during apical hook development in Arabidopsis thaliana seedlings.
Auxin induces expression of a previously uncharacterized auxin influx carrier LAX3 (AT1G77690) in cortical and epidermal cells directly overlaying new primordia. Increased LAX3 activity reinforces auxin-dependent induction of cell-wall-remodelling enzymes
Title: The auxin influx carrier LAX3 promotes lateral root emergence.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_106418.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables auxin influx transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin import into cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within auxin polar transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lateral root formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to auxin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within root cap development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: uncharacterized protein

NP_177892.1

like AUX1 3 (LAX3); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: like AUXIN RESISTANT 2 (TAIR:AT2G21050.1); Has 1212 Blast hits to 1207 proteins in 154 species: Archae - 0; Bacteria - 0; Metazoa - 167; Fungi - 294; Plants - 716; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

29200417..29203418 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106418.4 → NP_177892.1 uncharacterized protein AT1G77690 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9CA25

UniProtKB/TrEMBL

A0A178W1L1, A0A5S9WV92

Conserved Domains (1) summary

PLN03074
Location:1 → 470

PLN03074; auxin influx permease; Provisional