SUMM2 LRR and NB-ARC domains-containing disease resistance protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: SUMM2
Official Full Name: LRR and NB-ARC domains-containing disease resistance protein
Primary source: TAIR:AT1G12280
Locus tag: AT1G12280
See related: Araport:AT1G12280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F5O11.34; F5O11_34; suppressor of mkk1 mkk2 2
Summary: Encodes a NB-LRR protein SUMM2 involved in defense response to bacterium.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity.
Title: Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4, resulted in a partial reversion of the CA-MPK3 phenotypes.
Title: Constitutively Active Arabidopsis MAP Kinase 3 Triggers Defense Responses Involving Salicylic Acid and SUMM2 Resistance Protein.
SUMM2 is an Arabidopsis R protein that becomes active when the MEKK1-MKK1/MKK2-MPK4 cascade is disrupted by pathogens.
Title: Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_101100.2

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

Preferred Names: LRR and NB-ARC domains-containing disease resistance protein

NP_172692.1

LRR and NB-ARC domains-containing disease resistance protein; FUNCTIONS IN: ATP binding; INVOLVED IN: N-terminal protein myristoylation, defense response, apoptosis; LOCATED IN: endomembrane system; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (CC-NBS-LRR class) family (TAIR:AT1G12220.2); Has 17827 Blast hits to 16139 proteins in 646 species: Archae - 26; Bacteria - 895; Metazoa - 2143; Fungi - 215; Plants - 14237; Viruses - 0; Other Eukaryotes - 311 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain