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    CG44247 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 19835727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG44247provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265182
    Locus tag
    Dmel_CG44247
    See related
    AllianceGenome:FB:FBgn0265182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Atf-2; CG30420; CG3749; Dmel\CG44247; FBgn0050420
    Summary
    Predicted to be located in membrane. Is expressed in several structures, including CNS surface glial cell; antennal disc; embryonic/larval dorsal vessel; presumptive arista; and wing pouch. Orthologous to human NPDC1 (neural proliferation, differentiation and control 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG44247 in Genome Data Viewer
    Location:
    60E4-60E5; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24876691..24881221)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20764214..20768744)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Activating transcription factor-2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466 Neighboring gene Na,K-ATPase Interacting Neighboring gene Ance-5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects. Uchino R, et al. Dev Biol, 2013 Jan 1. PMID 22982669
    2. Canalization of gene expression is a major signature of regulatory cold adaptation in temperate Drosophila melanogaster. von Heckel K, et al. BMC Genomics, 2016 Aug 8. PMID 27502401, Free PMC Article
    3. Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis. Clemente-Ruiz M, et al. Dev Cell, 2016 Feb 8. PMID 26859353
    4. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division. Manzanero-Ortiz S, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768763, Free PMC Article
    5. Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila. Cattenoz PB, et al. Front Cell Dev Biol, 2021. PMID 33748138, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG44247-PA
    CG44247-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24876691..24881221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138130.4 → NP_611974.2  uncharacterized protein Dmel_CG44247, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611974.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP1, Q9W0Z3, Q9W0Z5
      Conserved Domains (1) summary
      pfam06809
      Location:329 → 459
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

    2. NM_166690.3 → NP_726489.2  uncharacterized protein Dmel_CG44247, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726489.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP1, Q9W0Z3, Q9W0Z5
      Conserved Domains (1) summary
      pfam06809
      Location:329 → 459
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0Z5 Q9W0Z5

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials