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    DHAR2 dehydroascorbate reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843864, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DHAR2
    Official Full Name
    dehydroascorbate reductase 2
    Primary source
    TAIR:AT1G75270
    Locus tag
    AT1G75270
    See related
    Araport:AT1G75270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    dehydroascorbate reductase 2; F22H5.1; F22H5_1
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    Genomic context

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    See DHAR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (28250075..28251469, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene oxidoreductases, acting on NADH or NADPH Neighboring gene miscRNA Neighboring gene NmrA-like negative transcriptional regulator family protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosolic dehydroascorbate reductase is important for ozone tolerance in Arabidopsis thaliana. Yoshida S, et al. Plant Cell Physiol, 2006 Feb. PMID 16361320
    2. Arabidopsis dehydroascorbate reductase 1 and 2 modulate redox states of ascorbate-glutathione cycle in the cytosol in response to photooxidative stress. Noshi M, et al. Biosci Biotechnol Biochem, 2017 Mar. PMID 27852156
    3. Cytosolic and Chloroplastic DHARs Cooperate in Oxidative Stress-Driven Activation of the Salicylic Acid Pathway. Rahantaniaina MS, et al. Plant Physiol, 2017 Jun. PMID 28381499, Free PMC Article
    4. Dehydroascorbate Reductases and Glutathione Set a Threshold for High-Light-Induced Ascorbate Accumulation. Terai Y, et al. Plant Physiol, 2020 May. PMID 32205453, Free PMC Article
    5. Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana. Dixon DP, et al. J Biol Chem, 2002 Aug 23. PMID 12077129

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that (1) DHAR can be decreased to negligible levels without marked effects on ascorbate pools, (2) the cytosolic isoforms are particularly important in coupling intracellular hydrogen peroxide metabolism to glutathione oxidation, and (3) DHAR-dependent glutathione oxidation influences redox-driven salicylic acid accumulation.
      Title: Cytosolic and Chloroplastic DHARs Cooperate in Oxidative Stress-Driven Activation of the Salicylic Acid Pathway.
    2. The role of DHAR2 in the modulation of cellular redox in the cytosol in response to photooxidative stress
      Title: Arabidopsis dehydroascorbate reductase 1 and 2 modulate redox states of ascorbate-glutathione cycle in the cytosol in response to photooxidative stress.
    3. ozone exposure increased the expression of the cytosolic DHAR gene; results indicate that the apoplastic ascorbate, which is generated through the reduction of dehydroascorbate by cytDHAR, is important for ozone tolerance
      Title: Cytosolic dehydroascorbate reductase is important for ozone tolerance in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_106182.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione dehydrogenase (ascorbate) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within acquisition of seed longevity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascorbate glutathione cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of salicylic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein glutathionylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    dehydroascorbate reductase 2
    NP_177662.1
    • dehydroascorbate reductase 2 (DHAR2); FUNCTIONS IN: glutathione binding, glutathione dehydrogenase (ascorbate) activity; INVOLVED IN: protein amino acid glutathionylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: dehydroascorbate reductase (TAIR:AT1G19570.1); Has 4940 Blast hits to 4851 proteins in 1062 species: Archae - 0; Bacteria - 1874; Metazoa - 1090; Fungi - 227; Plants - 921; Viruses - 0; Other Eukaryotes - 828 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28250075..28251469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106182.4 → NP_177662.1  dehydroascorbate reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LB28, Q9FRL8
      UniProtKB/TrEMBL
      A0A178WD32, A0A5S9WUJ8
      Conserved Domains (3) summary
      PLN02378
      Location:1 → 212
      PLN02378; glutathione S-transferase DHAR1
      cd03201
      Location:89 → 210
      GST_C_DHAR; C-terminal, alpha helical domain of Dehydroascorbate Reductase
      pfam13417
      Location:19 → 88
      GST_N_3; Glutathione S-transferase, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FRL8.1

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