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    ELC Ubiquitin-conjugating enzyme/RWD-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820419, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ELC
    Official Full Name
    Ubiquitin-conjugating enzyme/RWD-like protein
    Primary source
    TAIR:AT3G12400
    Locus tag
    AT3G12400
    See related
    Araport:AT3G12400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATELC
    Summary
    Mutants of this gene were initially identified because of the trichome morphogenesis phenotype. Those trichomes have multiple nuclei, a defect that turns out not to be restricted to the trichomes but also in all endoreduplicating cell types. This gene encodes a ubiquitin-binding protein with sequence similarities with yeast proteins that are components of the ESCRTI-III complexes. The Arabidopsis protein is found associated with the endosome.
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    Genomic context

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    See ELC in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (3943760..3945863, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene actin-related protein 5 Neighboring gene tRNA-Lys Neighboring gene Nascent polypeptide-associated complex (NAC), alpha subunit family protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole. Zhao J, et al. J Cell Biol, 2022 Dec 5. PMID 36260289, Free PMC Article
    2. ESCRT-I Component VPS23A Is Targeted by E3 Ubiquitin Ligase XBAT35 for Proteasome-Mediated Degradation in Modulating ABA Signaling. Yu F, et al. Mol Plant, 2020 Nov 2. PMID 32919085
    3. A unique plant ESCRT component, FREE1, regulates multivesicular body protein sorting and plant growth. Gao C, et al. Curr Biol, 2014 Nov 3. PMID 25438943
    4. SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling. Xia FN, et al. Plant Cell, 2020 Oct. PMID 32753431, Free PMC Article
    5. The Arabidopsis ESCRT protein-protein interaction network. Shahriari M, et al. Plant Mol Biol, 2011 May. PMID 21442383

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT-I Component VPS23A Is Targeted by E3 Ubiquitin Ligase XBAT35 for Proteasome-Mediated Degradation in Modulating ABA Signaling.
      Title: ESCRT-I Component VPS23A Is Targeted by E3 Ubiquitin Ligase XBAT35 for Proteasome-Mediated Degradation in Modulating ABA Signaling.
    2. SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.
      Title: SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112075.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trichome branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ubiquitin-conjugating enzyme/RWD-like protein
    NP_566423.1
    • ELC; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Tumour susceptibility gene 101 (InterPro:IPR008883), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608), Steadiness box (InterPro:IPR017916); BEST Arabidopsis thaliana protein match is: ELCH-like (TAIR:AT5G13860.1); Has 587 Blast hits to 537 proteins in 178 species: Archae - 0; Bacteria - 3; Metazoa - 278; Fungi - 177; Plants - 63; Viruses - 0; Other Eukaryotes - 66 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3943760..3945863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337991.1 → NP_001327160.1  Ubiquitin-conjugating enzyme/RWD-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRG3

    2. NM_001337992.1 → NP_001327159.1  Ubiquitin-conjugating enzyme/RWD-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRG2

    3. NM_112075.3 → NP_566423.1  Ubiquitin-conjugating enzyme/RWD-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566423.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LHG8
      UniProtKB/TrEMBL
      A0A178VBS4, A0A5S9XBD2
      Conserved Domains (2) summary
      pfam05743
      Location:37 → 156
      UEV; UEV domain
      pfam09454
      Location:316 → 375
      Vps23_core; Vps23 core domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LHG8.1

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