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    ETG1 E2F target protein 1 (ETG1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818650, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ETG1
    Official Full Name
    E2F target protein 1 (ETG1)
    Primary source
    TAIR:AT2G40550
    Locus tag
    AT2G40550
    See related
    Araport:AT2G40550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    E2F target gene 1; T2P4.10; T2P4_10
    Summary
    Encodes a nuclear localized target of E2Fa-DPa, transcription factors controlling cell cycle progression. Required for sister chromatid cohesion and DNA repair.
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    Genomic context

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    See ETG1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (16934621..16938272)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Nucleotidyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene potassium transporter 2 Neighboring gene Protein kinase superfamily protein Neighboring gene initiator tRNA phosphoribosyl transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. Takahashi N, et al. PLoS Genet, 2010 Jan 15. PMID 20090939, Free PMC Article
    2. The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. Takahashi N, et al. EMBO J, 2008 Jul 9. PMID 18528439, Free PMC Article
    3. Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network. Boruc J, et al. Plant Cell, 2010 Apr. PMID 20407024, Free PMC Article
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129617.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    E2F target protein 1 (ETG1)
    NP_181587.2
    • E2F target gene 1 (ETG1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: sister chromatid cohesion, postreplication repair, DNA replication; LOCATED IN: nuclear replisome, nucleus, chloroplast envelope, MCM complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF2044, membrane (InterPro:IPR019140); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16934621..16938272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129617.5 → NP_181587.2  E2F target protein 1 (ETG1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181587.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22880, Q0WST4, Q501D5
      UniProtKB/TrEMBL
      A0A178VQR6, A0A5S9X5S7, A0A654F1W9
      Conserved Domains (1) summary
      pfam09739
      Location:44 → 585
      MCM_bind; Mini-chromosome maintenance replisome factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q501D5.1

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