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    NAC069 NAC domain containing protein 69 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828144, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAC069
    Official Full Name
    NAC domain containing protein 69
    Primary source
    TAIR:AT4G01550
    Locus tag
    AT4G01550
    See related
    Araport:AT4G01550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    anac069; ANAC069; F11O4.5; F11O4_5; NAC domain containing protein 69; NAC with Transmembrane Motif 2; NTM2
    Summary
    Encodes a plasma-membrane bound NAC transcription factor, whose controlled proteolytic activation allows it to enter the nucleus.
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    Genomic context

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    See NAC069 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (673862..676445, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NAC with transmembrane motif1 Neighboring gene Ribosomal RNA processing Brix domain protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene serine protease inhibitor, Kazal-type family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ANAC069 binds to C[A/G]CG[T/G] sequences to negatively regulate salt and osmotic stress tolerance. He L, et al. Plant Mol Biol, 2017 Mar. PMID 27975189
    2. Auxin modulation of salt stress signaling in Arabidopsis seed germination. Jung JH, et al. Plant Signal Behav, 2011 Aug. PMID 21757997, Free PMC Article
    3. Integration of auxin and salt signals by the NAC transcription factor NTM2 during seed germination in Arabidopsis. Park J, et al. Plant Physiol, 2011 Jun. PMID 21450938, Free PMC Article
    4. ATDOF5.8 protein is the upstream regulator of ANAC069 and is responsive to abiotic stress. He L, et al. Biochimie, 2015 Mar. PMID 25572919
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that ANAC069 regulates the expression of genes mainly through interacting with the DNA sequence C[A/G]CG[T/G] in response to abiotic stresses.
      Title: Arabidopsis ANAC069 binds to C[A/G]CG[T/G] sequences to negatively regulate salt and osmotic stress tolerance.
    2. ATDOF5.8 regulates the expression of ANAC069
      Title: ATDOF5.8 protein is the upstream regulator of ANAC069 and is responsive to abiotic stress.
    3. NTM2 is a molecular link that incorporates auxin signal into salt stress signaling during seed germination.
      Title: Auxin modulation of salt stress signaling in Arabidopsis seed germination.
    4. Auxin delays seed germination under high salinity through cross talk with the NTM2-mediated salt signaling in Arabidopsis.[NTM2]
      Title: Integration of auxin and salt signals by the NAC transcription factor NTM2 during seed germination in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084875.1
    NM_116385.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAC domain containing protein 69
    NP_001078344.1
    • NAC domain containing protein 69 (NAC069); BEST Arabidopsis thaliana protein match is: NAC with transmembrane motif1 (TAIR:AT4G01540.1); Has 58 Blast hits to 56 proteins in 4 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 2; Plants - 56; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_192064.1
    • NAC domain containing protein 69 (NAC069); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: multicellular organismal development, regulation of transcription; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: NAC with transmembrane motif1 (TAIR:AT4G01540.1); Has 2746 Blast hits to 2733 proteins in 77 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 2; Plants - 2744; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      673862..676445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116385.4 → NP_192064.1  NAC domain containing protein 69 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRW7, O82590, Q9M126
      UniProtKB/TrEMBL
      A0A178V081
      Conserved Domains (1) summary
      pfam02365
      Location:7 → 47
      NAM; No apical meristem (NAM) protein

    2. NM_001084875.1 → NP_001078344.1  NAC domain containing protein 69 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M126
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M126.1

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