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    CLPR4 CLP protease R subunit 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827412, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLPR4
    Official Full Name
    CLP protease R subunit 4
    Primary source
    TAIR:AT4G17040
    Locus tag
    AT4G17040
    See related
    Araport:AT4G17040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLP protease R subunit 4; DL4550C; FCAALL.413; happy on norflurazon 5; HON5
    Summary
    HON5 (At4g17040) encodes the ClpR4 subunit of the chloroplast-localized Clp protease complex. hon mutations disturb plastid protein homeostasis, thereby activating plastid signaling and inducing stress acclimatization.
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    Genomic context

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    See CLPR4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (9585283..9589376, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transcription factor IIIB Neighboring gene transcription factor-like protein Neighboring gene expansin-like B1 Neighboring gene ureidoglycine aminohydrolase Neighboring gene FRIGIDA interacting protein 2 Neighboring gene peptidyl-prolyl cis-trans isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 'happy on norflurazon' (hon) mutations implicate perturbance of plastid homeostasis with activating stress acclimatization and changing nuclear gene expression in norflurazon-treated seedlings. Saini G, et al. Plant J, 2011 Mar. PMID 21208309
    2. Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis. Wu W, et al. Plant J, 2013 Dec. PMID 24124904
    3. Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis. Kim J, et al. Plant Physiol, 2013 May. PMID 23548781, Free PMC Article
    4. Subunit stoichiometry, evolution, and functional implications of an asymmetric plant plastid ClpP/R protease complex in Arabidopsis. Olinares PD, et al. Plant Cell, 2011 Jun. PMID 21712416, Free PMC Article
    5. Identification of a 350-kDa ClpP protease complex with 10 different Clp isoforms in chloroplasts of Arabidopsis thaliana. Peltier JB, et al. J Biol Chem, 2001 May 11. PMID 11278690

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The virescent clpR4-3 mutation suppresses leaf variegation of thf1 and var2.
      Title: Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis.
    2. Comparison of the proteomics phenotype of clpp3-1 with the clpr2-1 and clpr4-1 phenotypes indicated very similar metabolic and protein homeostasis defects for these Clp core mutants.
      Title: Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117808.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 
    located_in plastid stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLP protease R subunit 4
    NP_567521.1
    • CLP protease R subunit 4 (CLPR4); FUNCTIONS IN: serine-type endopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: plastid stroma, chloroplast, chloroplast stroma, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S14, ClpP (InterPro:IPR001907); BEST Arabidopsis thaliana protein match is: ATP-dependent caseinolytic (Clp) protease/crotonase family protein (TAIR:AT1G09130.3); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9585283..9589376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117808.3 → NP_567521.1  CLP protease R subunit 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23548, Q8LB10, Q8RXG1
      UniProtKB/TrEMBL
      A0A178V785, A0A5S9XTG5
      Conserved Domains (1) summary
      cd07017
      Location:105 → 283
      S14_ClpP_2; Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LB10.1

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