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    CG6650 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39555, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG6650provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036402
    Locus tag
    Dmel_CG6650
    See related
    AllianceGenome:FB:FBgn0036402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0670/06; anon-WO0172774.121; anon-WO0172774.122; anon-WO0172774.123; Dmel\CG6650; l(3)067006; l(3)S067006
    Summary
    Predicted to enable ADP-specific glucokinase activity. Predicted to be involved in glucose metabolic process. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; organism; and spermatozoon. Orthologous to human ADPGK (ADP dependent glucokinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6650 in Genome Data Viewer
    Location:
    70C15-70C15; 3-41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14031450..14034909)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14024550..14028009)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene upSET Neighboring gene PAX transcription activation domain interacting protein Neighboring gene antisense RNA:CR42871 Neighboring gene endosulfine Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 110 Neighboring gene Neuralized E3 ubiquitin protein ligase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bypassing the Greatwall-Endosulfine pathway: plasticity of a pivotal cell-cycle regulatory module in Drosophila melanogaster and Caenorhabditis elegans. Kim MY, et al. Genetics, 2012 Aug. PMID 22649080, Free PMC Article
    2. Regulation of sumo mRNA during endoplasmic reticulum stress. Moore KA, et al. PLoS One, 2013. PMID 24058701, Free PMC Article
    3. Genetic and molecular analysis in the 70CD region of the third chromosome of Drosophila melanogaster. Burmester T, et al. Gene, 2000 Apr 4. PMID 10767537
    4. Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis. Rangone H, et al. PLoS Genet, 2011 Aug. PMID 21852956, Free PMC Article
    5. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. He L, et al. Elife, 2019 May 29. PMID 31140975, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ADP-specific glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-specific glucokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6650-PA
    CG6650-PB
    CG6650-PC
    NP_001246747.1
    NP_001287066.1
    NP_648685.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14031450..14034909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140428.4 → NP_648685.1  uncharacterized protein Dmel_CG6650, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB9
      Related
      FBpp0075511
      Conserved Domains (1) summary
      cd01938
      Location:23 → 501
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

    2. NM_001300137.1 → NP_001287066.1  uncharacterized protein Dmel_CG6650, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB9
      Conserved Domains (1) summary
      cd01938
      Location:23 → 501
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

    3. NM_001259818.2 → NP_001246747.1  uncharacterized protein Dmel_CG6650, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB9
      Conserved Domains (1) summary
      cd01938
      Location:23 → 501
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGM3 Q8IGM3
    Q9VUB9 Q9VUB9

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