chm chameau [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chmprovided by FlyBase
Official Full Name: chameauprovided by FlyBase
Primary source: FLYBASE:FBgn0028387
Locus tag: Dmel_CG5229
See related: AllianceGenome:FB:FBgn0028387
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5229; Chm; Dmel\CG5229; dmHAG404; HAT; HAT1; HBO1
Summary: Enables DNA-binding transcription factor binding activity; histone acetyltransferase activity; and transcription coactivator activity. Involved in several processes, including imaginal disc fusion, thorax closure; regionalization; and regulation of gene expression. Located in nucleus. Is expressed in embryonic brain and organism. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27F3-27F4; 2-26 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7412417..7422736)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7412417..7422736)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel role has been described for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.
Title: A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.
results suggest that EAChm regulates gene transcription in Drosophila embryos by enhancing Acetyltransferase Chameau activity
Title: Enhancer of Acetyltransferase Chameau (EAChm) Is a Novel Transcriptional Co-Activator.
data suggest that Chm and CBP might function both locally at the amplicon origins and globally in the developmental transition of follicle cells into the amplification stage of oogenesis
Title: The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells.
Evidence that the protein Chameau (chm) restricts the singling out of sensory organ precursors from proneural clusters and genetically interacts with transcriptional regulators involved in the regulation of achaete and scute in the extra-dorsocentral and scutellar proneural cluster.
Title: The MYST-containing protein Chameau is required for proper sensory organ specification during Drosophila thorax morphogenesis.
role in gene silencing
Title: The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histone acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericentric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of histone H3-K14 acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chameau

Names: CG5229-PA; CG5229-PB; CG5229-PC; chm-PA; chm-PB; chm-PC

NP_001245930.1

EC 2.3.1.48

NP_001260192.1

EC 2.3.1.48

NP_609117.4

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

7412417..7422736

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273263.1 → NP_001260192.1 chameau, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260192.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NHW0, Q9VM15

Conserved Domains (3) summary

pfam01530
Location:376 → 402

zf-C2HC; Zinc finger, C2HC type

pfam01853
Location:584 → 766

MOZ_SAS; MOZ/SAS family

cl17182
Location:526 → 802

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
NM_135273.5 → NP_609117.4 chameau, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609117.4

Status: REVIEWED

UniProtKB/TrEMBL

Q9NHW0, Q9VM15

Related

FBpp0079071

Conserved Domains (3) summary

pfam01530
Location:376 → 402

zf-C2HC; Zinc finger, C2HC type

pfam01853
Location:584 → 766

MOZ_SAS; MOZ/SAS family

cl17182
Location:526 → 802

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
NM_001259001.2 → NP_001245930.1 chameau, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245930.1

Status: REVIEWED

UniProtKB/TrEMBL

D8FT35, M9NEW2

Conserved Domains (2) summary

pfam01530
Location:376 → 402

zf-C2HC; Zinc finger, C2HC type

cl17182
Location:526 → 693

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate