CoRest CoRest [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CoRestprovided by FlyBase
Official Full Name: CoRestprovided by FlyBase
Primary source: FLYBASE:FBgn0261573
Locus tag: Dmel_CG42687
See related: AllianceGenome:FB:FBgn0261573
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH01486; BcDNA:LD11215; CG32534; CG32535; CG33525; CG3878; CG42687; CoREST; CoRESTG; dCoREST; Dmel\CG42687; i169
Old locus tag: Dmel_CG32534; Dmel_CG33525
Summary: Enables chromatin binding activity and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and transposable element silencing by piRNA-mediated heterochromatin formation. Located in nucleus. Part of transcription repressor complex. Is expressed in female germline cell; follicle cell; organism; and spermatozoon. Orthologous to human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18C8-18C8; 1-62 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19521929..19530896)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19415962..19424929)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
Title: Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
This study uncovers three distinct dCoREST complexes that function in a lineage-restricted fashion to repress specific sets of genes thereby maintaining cell-type-specific gene expression programmes.
Title: Distinct CoREST complexes act in a cell-type-specific manner.
The data indicate that CoREST acts as a positive modulator of the Notch pathway in the follicular epithelium as well as in wing tissue, and suggests a previously unidentified role for CoREST in the regulation of Notch signaling.
Title: CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: CoRest

Names: CG42687-PA; CG42687-PC; CG42687-PD; CG42687-PE; CG42687-PF; CG42687-PG; CG42687-PH; CG42687-PI; CG42687-PJ; CG42687-PK; CoRest-PA; CoRest-PC; CoRest-PD; CoRest-PE; CoRest-PF; CoRest-PG; CoRest-PH; CoRest-PI; CoRest-PJ; CoRest-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19521929..19530896

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014754.1 → NP_001014754.1 CoRest, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014754.1

Status: REVIEWED

UniProtKB/TrEMBL

D3PFE5

Conserved Domains (3) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001258824.1 → NP_001245753.1 CoRest, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245753.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAG1

Conserved Domains (4) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:540 → 582

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001201742.3 → NP_001188671.1 CoRest, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188671.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAG1

Conserved Domains (4) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:540 → 582

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001014752.4 → NP_001014752.2 CoRest, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014752.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4S3, Q494F9, Q59E35, Q59E36, Q8MSX7, Q95TC9, Q9VWH3

Conserved Domains (4) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:306 → 348

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001014753.3 → NP_001014753.1 CoRest, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q59E36

Conserved Domains (4) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:304 → 346

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001258825.2 → NP_001245754.1 CoRest, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245754.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAG1

Conserved Domains (4) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:540 → 582

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001014755.2 → NP_001014755.1 CoRest, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014755.1

Status: REVIEWED

UniProtKB/TrEMBL

D3PFE5

Conserved Domains (3) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001014756.2 → NP_001014756.1 CoRest, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014756.1

Status: REVIEWED

UniProtKB/TrEMBL

D3PFE5

Conserved Domains (3) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001272777.1 → NP_001259706.1 CoRest, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259706.1

Status: REVIEWED

UniProtKB/TrEMBL

D3PFE5, M9PJR2

Conserved Domains (3) summary

smart00717
Location:179 → 225

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:92 → 144

ELM2; ELM2 domain

cl21498
Location:180 → 224

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001258826.1 → NP_001245755.1 CoRest, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245755.1

Status: REVIEWED

UniProtKB/TrEMBL

D5SHV0, M9NHB6

Conserved Domains (2) summary

smart00717
Location:52 → 97

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:52 → 94

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...